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DU PA Occ/int Lu Dis

Duke PA Occupational/Interstitial/GranulomatousLung Disease

a virtual space between individual alveoli interstitium
from inhalation of silica silicosis
The chest film will reveal diffuse rounded opacities, Contraction of the lungs may occur, Upper lung zones are primarily affected coal miner's lung
black lung coal miner's lung
occupational lung disease caused by the inhalation of dust pneumoconiosis
Most commonly associated with mining, insulation, shipbuilding, cement mixing and sandblasting related occupations silicosis
Higher rate of pulmonary tuberculosis in ____ patients silicosis
Hilar lymph nodes calcify forming “eggshell” calcifications on chest films silicosis
may lead to pleural disease characterized by plaques, effusion and fibrosis asbestosis
Mesothelioma, Bronchogenic Carcinoma are malignancies caused by asbestosis
“Pleural Plaques” are seen on chest films asbestosis
diagnosis is based largely on the history of exposure and latency period. 20-30 year exposure history asbestosis
Allergic pulmonary condition caused by inhalation of organic materials Hypersensitivity Pneumonitis
Known causative agents include bacteria, molds, human and animal proteins and resins Hypersensitivity Pneumonitis
Abrupt onset of fever, cough & dyspnea within 4-8 hours of exposureInfiltrates in the mid-to-lower lung distributionResolution within 24 hours, after removal from exposureOften mistaken for community-acquired pneumonia, treated with antibiotics Hypersensitivity Pneumonitis
Characterized as lung injury caused by the inhalation of nitrogen dioxide gas Silo-Filler’s Disease
Approximately ___ of patients admitted to the burn unit have pulmonary injury due to smoke inhalation 1/3
Carbon monoxide and cyanide poisoning impairs oxygenation causing tissue hypoxia smoke inhalation
Ensuing airway edema and mucosal sloughing occurs smoke inhalation
Routine use of corticosteroids and antibiotics has not been proven to be effective in treatment of smoke inhalation
Topical administration of epinephrine may be used to reduce airway edema smoke inhalation
The death rate among patients experiencing severe burn and inhalational injuries can be >__ 50%
_____ cannot differentiate carboxyhemoglobin from oxyhemoglobin. pulse oximetry
CO has a ____ higher affinity for hemoglobin than does oxygen 250 X
____ deposits in the alveoli and the interstitium results in irriversible fibrosis Fibrin
Loss of functional alveolar-capillary units,Impaired gas exchange that leads to hypoxemia and hypercapnia, Impaired lung compliance (stiff lungs)Progresses into Restrictive Lung Disease: smaller lung volumes and capacities (TLC, Tidal Volumes) interstitial lung disease
Patchy “Ground Glass” appearance, Reticular (network) pattern, Honeycombing (thick-walled cystic spaces) in the lung periphery interstitial lung disease
A nodular inflammatory lesion that may contain epithelial cells, phagocytes or macrophages granuloma
A form of coagulation necrosis caseating
A systemic disease of unknown origin characterized by granulomatous inflammation of the lung sarcoidosis
Systemic disorder involving multiple organ systems,Highest incidence in black women, Onset in the 3rd decade of life sarcoidosis
Elevated ESR, Leukopenia, Elevated ACE levels (40-80% prevalence) sarcoidosis
Requires tissue biopsy of a lymph node showing non-caseating granulomas sarcoidosis
Long-term corticosteroid therapy, ACE levels will tend to drop treatment for sarcoidosis
A condition characterized by the presence of vasculitis and granulomatous lesions affecting the respiratory tract and kidneys Wegener’s Granulomatosis
Small vessel vasculitis, Granuloma formation inflammation, Necrosis triad of symptoms for Wegener’s Granulomatosis
Nasal septum perforation, crusting and ulceration may present, Deep vein thrombosis and pulmonary emboli are common, “Saddle Nose” deformity is a late stage finding Wegener’s Granulomatosis
Idiopathic condition involving alveolar (lung) hemorrhage and rapidly progressive glomerulonephritis Goodpasture's syndrome
Most prevalent in men within the 3rd and 4th decade of life, Pathology is linked to glomerular antibodies Goodpasture's syndrome
Immunosuppressive Therapy is treatment for Goodpasture's syndrome
Created by: bwyche