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Adrenergic bronchodi
| Question | Answer |
|---|---|
| adrenergic receptors AKA | adrenoreceptors |
| these are a class of G- protein coupled receptors that r targets of catecholamines | adrenergic receptors |
| norepinephrine AKA | noradrenaline |
| adrenaline is AKA | apinephrine |
| 2 component of catecholamines are | eponephrine & norepinephrine |
| mast cells possess these receptors | binding of catecholamine 2 receptor= stimulation of sympathetic nervouse system |
| catecholamine receptors stimulate _ nervouse system | sympothetic |
| sympothetic nervouse system is responsiable for what bodys response | fight-or-flight response |
| most useful & potent group of Resp. care drugs primaryaly used to relax bronchial smooth muscle & dilates airway; 2ndly effects facillitate mucocilliary transport of secretion & promotes expectoration | adrenergic {sympathomimetic} bronchodilators |
| Both A&B adrenergic activity; if inhaled =quick onset {1-5}minutes; & metabolized quickly; Duration 1-3 hrs prevents release of histamine | epinephrine A&B |
| promote vasoconstriction both in priphery & in lungs= <capillary leakage | A adrenergic effects |
| relax bronchial smooth muscle; ^HR & cardiac contractility & inhibit further release of nnflammatory mediators | B adrenergic effects |
| Catecholamines are good for | ONLY the attck |
| all sympathomimetic B2 __ or derivatives of catecholamine | catecholamines |
| these sympathomimetic amines mimic epinephrine fairly closely | catecholamines |
| Dopamine epinephrine norepinephrine & isoproterenol are examples of.. | B2 sympathomimetic |
| these cause tachycardia elevated BP bronchial & skeletal smoothmuscle relaxation & skeletal muscle tremor & CNS stimulation | catecholamines/ epinephrine caution w/ CHF Pt |
| catecholamines are inactivated by_= limits actions of the drug to1.5-3 hrs; anr r inactivated by the gut {NEVER ORALLY} | COMT |
| catecholamines R also inactivated by _; _; _ they R stored in Amber bottles & residue tubing maybe pink colored | Heat light air |
| these R more B2 specific COMT can longer inactivate drug= duration is > up2 6hrs Can be taken orally cuz not effected by gut or liver | Resorcinols |
| even more B2 specific {albuterol} Available as MDI; Tab.: syrupp; aerosol solution; effective by mouth & up 2 6 hrs | Saligenins |
| levalbuterol (Xopenex) is most common B2 bronchodilator on market; others are Albuterol/Ventolin/Proventil | saligenins example drugs |
| serevent AKA | salmeterol |
| DONT USE IN ACUTE ATTCK lasts up2 12 hrs 2 puffs BIDonset 10-20 minutes w/ pk in 180 minutes | Salmeterol {servent} |
| ion of the bronchial smooth muscle (bronchodilation) 2. inhibits mast cell release 3. stimulates mucocilliary clearance | B2 stimulation effects |
| vasoconstriction | A1 adrenergic |
| ^HR ^inotropy ^conductivity | B1 adrenergic |
| B2 stimulation~ ^ adenyl cyclase~ ^ cAMP~ <intracellular Ca+2= | bronchodilation break down |
| in order for histamine 2 be released from the mast cells there must be free _ | free calcium |
| naturally occurs in the adrenal medulla rapid onset/ short duration do2 inactivated by COMT inhaled or S.C. | Epinephrine specific adrenergic agents |
| synthetic form of epinephrine action same as epinephrine + vasoconstrictor effect is 1/2 do to synthetic compensation Tx croup & ^airway swelling/edema | Racemic Epinephrine |
| non-Catecholamines | long duration 4-6hrs good 4 maintenance dose 4 BRONCHOPASM inhalation;oral;injection slow pk effect 30-60minutes |
| tis drug is different cuz administration form must be converted 2 active drug in the body +(pro-drug) | Bitoterol (tornalate) prodrug |
| tremor; tachycardia; headaches; ^BP;nervousness;dizziness N/V; | E of adrenergic agents |
| SE <after _ weeks do to tolerance to adregic agents | 2 weeks |
Created by:
aprince1
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