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Pathology
Question | Answer |
---|---|
Down Syndrome | Simian Crease, ALL, AML, Alzheimer's, VSD, ASD |
Plummer Vinson Syndrome | Fe Deficiency --> Atrophic glossitis, esophageal webs, anemia. Assoc w/ Esophageal SCC |
CEA | Carcinoembryonic Antigen: marker for Colon, Pancreatic, Gastric & Breast Cancer |
beta-hCG | Hydratiform moles, Choriocarcionomas, Gestational trophoblastic tumor |
CA-125 | Ovarian epithelial tumors (non-germ cell) |
Alk Phos | Paget's Disease, Bone Mets, Obstructive billiary disease |
TRAP | Tartrate-resistant acid phosphate: Hairy B-Cell leukemia |
CA-19-9 | Pancreatic Adenocarcinoma |
HHV-8 | kaposis sarcoma, body cavity fluid B-Cell lymphoma |
Liver Carcinogens | Vinyl Chloride, CCl4, Aflatoxins |
Esophagus Carcinogen | Nitrosamines (Smoked food) |
Bladder Carcinogens | Napthalene dyes |
Blood carcinogens | Alkylating agents |
SMALL Cell Lung Carcinoma Paraneoplastic Syndromes | ACTH(-like peptide)->Cushing, ADH->SIADH (also brain tumors), Anti-presynaptic Ca channel-> Lambert Eaton (muscle weakness) |
Paraneoplastic etiology of Hypercalcemia | Breast, Renal Carcinoma, SQUAMOUS Cell Lung Carcinoma |
Psammoma Bodies | Papillary Thyroid Ca, Serous Ovarian Ca, Mesothelioma, Meningioma |
Brain Mets | Lung, breast, melanoma |
Liver Mets | GI, breast, lung >>Primary |
Bone Mets | Prostate, Breasts >>Primary |
8;14 | Burkitt Lymphoma |
14;18 | Follicular Lymphoma |
9;22 | Chronic Myeloid Leukemia |
15;17 | Acute Promyelocytic Leukemia |
11;22 | Ewing Sarcoma |
von Hippel Lindenau | Cerebellar hemangioblastoma & elevated HCT, Renal hepatic & pancreatic cysts, renal cell carcinoma. Path:VHL LOF-> VEGF not degraded |
Berry anneurysm | AKA Saccular Aneurysm. Assoc. w/ ADCKD, Marfan, Ehlers Danlos Syndrome |
Neurofibromatosis 1 | Neural tumors, Cafe au Lait, Pheochromocytomas, Lisch Nodules (brown raised specs on iris) (chr 17-# of letters in neurofibromatosis) |
7alpha hydroxylase | Converts Cholesterol -> Bile acid |
Syringomyelia | Hand weakness, cape distribution of DC loss. Associated w/ Chiari Malformation |
Ferritin | Iron storage protein |
Transferrin | Iron shuttling protein in plasma |
Etiology of Schistocytes | Shear stress: ecclampsia/HTN/Pulm HTN, DIC, Thrombotic Thrombocytopenic Purpura, Hemolytic Uremic Syndrome, Prostheses |
Hemolytic Uremic Syndrome | Endothelial injury -> platelet aggregation/thrombosis -> Vascular obstruction. Triggered by infx, chemicals, cytotkines |
Sarcoidosis | Hilar lymphadenopathy, skin lesions, ANGII, hypercalcemia, non-caseating lung granulomas |
Carcinoid | GI enterochromaffin cell tumor (serotonin, etc). Sx:Flushing, Diarhea, wheezing, peripheral edema |
c-ANCA+ | WEGNER's, Microscopic Polyangitiitis |
Henoch-Schonlein Purpura | IgA-> glomerular mesangium. Skin, abdominal pain, arthralgias, renal probs. |
Tuberous Sclerosis | Cardiac Rhabdomyoma (#1kids), SEGA (Seizures MR), Renal Angiomyolipoma. TSC1,2 |
ras | P21, membrane G-Prot. Colon Cancer (onco) |
c-myc | Burkitts Lymphoma (onco) |
bcl-2 | Follicular & Undifferentiated Lymphoma (onco) |
erb-B2 | Tyrosine Kinase. Breast, Ovarian, Gastric Carcinomas. HER-2/neu. (onco) |
L-myc | Lung tumor |
N-myc | Neuroblastoma |
ret | MEN1,2 |
c-kit | GIST |
DPC | Pancreatic Cancer. 18q. (Supp) |
DCC | Colon Cancer. 18q (Supp) |
APC | Colorectal Cancer |
P53 | Li Fraumeni. 17p. Brain, Breast, Adrenals. (Supp) |
RB | (13q) Retinoblastoma, Osteosarcoma |
BRCA-1 | Breast, Ovarian Cancer. 17q. (Supp) |
BRCA-2 | 13q. Male Breast. (Supp) |
WT1 | Wilms Tumor. 11p. (Supp) |
NF1/2 | Neurofibromatosis 1/2 |
p16 | Melanoma |
p16 | Melanoma |
S-100 | Melanoma, Astrocytoma & neural tumor |
Bombesin | Neuroblastoma, lung & gastric cancer |
Acanthosis Nigricans | Visceral malignancy |
UC | Colonic adenocarcinoma |
p16 | Melanoma |
S-100 | Melanoma, Astrocytoma & neural tumor |
Bombesin | Neuroblastoma, lung & gastric cancer |
Acanthosis Nigricans | Visceral malignancy |
UC | Colonic adenocarcinoma |
HNPCC | Ovarian non-germ cell tumors. Colon Cancer |
p-ANCA+ | Churg-Straus, Microscopic Polyangitis |