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Phase 2 - Block 2 RX
Phase 2 - block 2 cardiac drugs
Question | Answer |
---|---|
Agonist | drugs possessing receptor affinity and intrinsic activity |
Antagonist | drugs that have receptor affinity for particular receptor but unable to produce intrinsic activity |
Intrinsic activity | biochemical response by the cell once a receptor have been activated |
Drugs | facilitate or inhibit the normal functions of a particular tissue |
Receptor affinity | drugs that bind to a specific receptor are claimed to have receptor affinity and may or may not generate intrinsic activity within the cell |
Receptor | chemical component on the surface of cell membranes (are the site of action) |
Somatic | voluntary, motor neurons, stimulates contraction of skeletal muscle |
Autonomic | involuntary |
Sympathetic | fight or flight - release norepinephrine |
Parasympathetic | conservation - release acetylcholine |
Adrenergic agonists | also known as sympathetic or adrenergic drugs |
Sympathomimetics | drugs that imitate sympathetic stimulation / alpha and beta receptors |
Alpha receptor | smooth muscle contraction |
Beta 2 receptor | smooth muscle relaxation |
Beta 1 receptor | cardiac stimulation |
Adrenergic antagonists | block actions of neurotransmitters; adrenergic blockers, antagonists, beta blockers, alpha blockers, inotropic drugs (vasoconstrictor / vasodilator, anti-hypertensives, anti-anginyls) |
Beta blockers | inhibits beta receptors - decrease HR, contractility, myocardial O2 demands and cardiac output. SA node discharge rate is reduced and conduction time of AV node increased. |
Beta blockers used to treat | angina, arrhythmias, and systemic hypertension |
Beta blocker drugs | -olol ; B CANT TLL MC TIC |
Calcium channel blockers | affect electrophysiology and mechanical properties of the heart, vasodilator |
Calcium channel blockers treat | a-fib, svt, a-flutter; systemic hypertension and hypertrophic cardiomyopathy |
Angiotension-converting enzymes (ACE Inhibitors) - (-il) | prevent angiotensin I from converting to a substance that retains salt and water (causing vessel relaxation) |
Angiotension Receptor Blockers - ARBs | blood vessels constrict |
Antiadrenergic agents | stimulates alpha-adrenergic receptors of CNS - dropping BP |
Antianginal/Nitrates | treats angina |
Diuretics | prevent fluid retention, reducing BP |
Direct Acting on vascular | dilation of vascular system - arterial or venous |
Vasopressor/Inotropes | vasoconstriction and release norepinephrine |
Cardiac Glycosides treats | CHF, SVT, tachy, a-fib; decrease AV node conduction rates |