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Aromatic Substituent
Order of Reactivity for Aromatic Substitution
Degree of Activation | Substituents |
---|---|
Very Strongly Activating | -OH -NH2,NHR,NR2 (O,P Directing) |
Strongly Activating | -OCH3 -OCR=O (phenol ester) -NH-CR=O (O,P Directing) |
Activating | -Alkyl, aryl, alkenyl (sigma domains) (O,P Directing) |
Deactivating | -Cl, F, Br, I -CH2OH, CH2Cl (O,P Directing) |
Strongly Deactivating | -COH=O, COR=O, CR=O, CH=O -SO3H -CN (M Directing) |
Very Strongly Deactivating | -NO2 -CF3 (M Directing) |