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Pharmacology

Veterinary Endocrine

QuestionAnswer
gonadotrophins in general act like GnRH, LH, FSH to increase ovulation, stimulate follicle formation SE:endometrial hyperplasia, follicular cysts
gonadorelin Cystorelin, Factrel, treats cystic ovaries in cows (induces estrus in cat/horse)
Chorionic gonadotrophin (hGC) Chorulon, LH activity, treats cystic ovaries in cattle
FSH-P (pituitary) compounded, superovulation: out of season breeding
PMSG, serum gonadotrophin Folligon,
Estrogens in general inhibit ovulation, increase uterine tone
Estradiol cypionate Estrus, Treats persistant CL, expels purulent materials from the uterus, RP and mummified fetus in cows, used as growth implants as well. Mismate injection in dogs/cats (toxic to bone marrow, pyometra causing)
Diethylstilbesterol not used in repro - used in urinary incontinence, perianal adenomas, prostatic hyperplasia NOT USED IN FOOD ANIMALS - linked to cervical cancer in women
Testosterone Testopal, promotes anabolism, weight gain, RBC formation, used to treat urinary incontinence SE: aggressive behavior, prostatic carcinoma, caution with renal/hepatic/cardiac disease patients, exacerbate perianal adenomas, infertility, decrease insulin
megestrol acetate Ovaban, Megace, AE: cats = adrenal atrophy (iatrogenic addisons) or can cause diabetes
Medroxyprogesterone Depo Provera, treats behavioral disorders
Altrenogest Regumate, minimal side effects, CI in pregnant mares, careful when handling, wash off immediately if contacts skin, may cause prolonged gestation in women Combined with estrogents to make growth implants
Progestins in general Uses: 1. cats = skin, urine spraying, aggression, delay estrus 2.dogs=aggression, delay estrus, false pregancy 3. horses = timing estrus, supplement preg mares 4. cattle = growth implants. SE: increased appetite, endometrial hyperplasia
CIDR Implant Progestin used in dairy cattle to synchronize estrus
MGA premix Melegestrol, used to suppress estrus in heifers at feedlot
Uterine contractility prostaglandins in general 6 classes, only prostaglandin F2 group is used in reproductive medicine, cause uterine contraction and relaxation of the cervix, caution for pregnant woman or asthmatics to handle. Used when animal has a corpus luteum, not used in swine
Dinoprost Lutalyse, SE: mares sweat profusely and exhibit colic symptoms dues to discomfort from uterine contractions
Cloprostenol Estrumate
Oxytocin causes uterine contraction NOT cervical dilation, caution when using in dystocia (BE SURE CERVIX is dilated), milk let down, corrects dystocia, uterine inertia, prolapsed uterus, evacuate uterus, retained placenta, stops pp hemorrhage, induces labour in m
Clenbuterol Ventipulmin, illegal in food animals, decrease uterine contractility in mares during a dystocia (facilitate fetal manipulation, b2 agonist
Corticosteroids can cause uterine contraction in late pregnancy (often causes abortion), expel contents of uterus
SOA Sex odor aerosol, used for estrus detection in sows, same effects as the smell of a boar
Feliway Analog of feline facial pheremones, calms cats down
levothyroxine Thyro Tabs, Synthroid, Soloxine, treats hypothyroidism, natural/treatment of choice, T4
liothyronine Cytobin, used when patients don't respond to T4, T3 compound
methimazole Tapazole, treats hyperthyroidism in cats, interferes with the incorporation of iodine into precursor molecules of T3, T4, not a cure, tabs given indefinately
Radioactive Iodine I-131, treatment of choice to kill thyroid, stop hyperactivity, expensive, chemotherapy, given IV, hyperactive thyroid cells pick it up, bring it home and destroy normal cells, treat with one dose, cat goes to clinic (hospital) for one month
Propranolol Inderal, management of tachycardia caused by hyperthyroidism (preventative), beta blocker
Insulin in general 2 types of DM (insulin dependant/non) Avoid giving with corticosteroids, epi, progesterone as these will increase blood glucose. Classified by duration of action and source
Caninsulin Medium
Toronto Short
NPH Medium
Semilente Short
PZI Long
Lantis Used in cats, long acting
Humulin-R Regular insulin, human product, IV, inclinic use
Growth hormones in general Male/female sex hormones +/- anabolics, increase weight gain, compressed SQ pellet, inserted in caudal ear, discarded at slaughter, not for dairy, breeding animals SE: symptoms of estrus or preg. (mounting, udder development), treats debilitated animals
Stanozolol Winstrol, anabolic
Boldenone Equipose
Nandrolone Deca-Durabolin
Testosterone Anadiol, Anatest
Anabolic agents treat older animals to increase appetite and well being, illegal in sport horses, cannot use in food animals, contraindicated in breeding/young growing animals SE: masculinization, aggression, hair, shrinking testicles
ACTH Uni-Cort, Stimulation tests for cushings and addisongs, test to see if adrenal will produce cortisol properly
Fludrocortisone Florinef, mineralocorticoid used in the treatment of addisons disease
Created by: jtwilks on 2008-12-15



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