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Genomic Organization

What are the three sequence classes of genomes Highly Repetitive,Intermediate, Rare
This genome class has up to a million copies per genome Highly repetitive
This genome class has a hundred to thousands of copies per genome Intermediate
This genome class has usually one copy per genome Rare
This genome class does not usually encode genes. Its function is structural Highly repetitive
A repeat of a genome with the same sequence over and over, end to end Tandem array
The majority of this genome class are degenerate transposons, particularly retrotransposons Intermediate
Sequences capable of moving from one location in the genome to another Transposons
Parasitic DNA molecules capable of moving from once cell to another with the use of an RNA intermediate Retroviruses
One of the most abundant transposable elementes in our genome Alu sequences
rRNAs, 5S-rRNA, tRNAs and histones are functional genes belonging to what class of genome Intermediate
How are intermediate class gens usually arranged In clusters
The largest of the three classes of genomes Rare
Most functional gene belong to this class of genome Rare
Groups of gene which are classified together because they have regions with similar, but not necessarily identical sequences Gene Families
Gene family members are beleived to be ..., which means they evolved from a common ancestral gene Homologous
An estimate of how closely related gens are based on sequence similarity Homology
The regions where there is very little change in sequence between homologous genes Conserved domains
The most common bases (or residue) at each position on a sequence analysis Consensus sequence
Gene families that are group closely together on the chromosome. They differ from tandem repeats because they are not identical, not as contigous, and the gens are not necessarily oriented in the same direction Clustered gene families
Geneomic sequences similar to expressed genes, but which have been mutated so they no longer express a gene product Pseudogenes
A clinical condition where fetal gamma globin expression persists throughout life. Hereditary persistnece of fetal hemoglobin
Defective alpha or beta globins. With severe cases, red blood cells die in bone marrow resulting in thinned bone cortex, fractures and distoriton s of the head, marked enlargement of liver and spleen and death within a decade. Thalassemias
Created by: mhaynes