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pharm final
ch 18
Question | Answer |
---|---|
epi | can be admin subQ, IV, topically, inhalation, intracardiac it is not given orally because it is rapidly metabolized by the liver and excreted in urine |
epi | used in emergencies treats anaphylaxis potent inotropic - ↑contractility, promotes vasoconstriction, and CO high doses can result in dysrhythmias - must be on ECG monitor |
epi and digoxin | dysrhythmia |
epi and beta blockers | antagonizes the action of epi |
epi and MAOIs | make epi's effects intensified and prolonged |
antedote for extravasation of norepi and dopamine | ☺phentolamine mesylate (regitine), 5-10 mg diluted in 10-15 mL of saline infiltrated into area for IV extravasation ☻redness and tissue warmth are signs of effective treatment |
atenolol and metropolol | ☺selective ☻↓BP and pulse |
atenolol (Tenornmin) | ☺selective beta blocker ☻CI in bradycardia, heart block, cardiogenic shock, pulm edema, acute bronchospasm, and pregnancy ♥once per day dosing ♦PO: onset 1 hr, peak 2-4 hrs, duration 24 |
doxazosin (Cardura) | alpha1-adrenergic blocker ☺treats HTN and BPH ☻s/e: dizziness, HA, syncope |
atenolol (Tenormin) | beta1-adrenergic blocker ☺HTN, angina, dysrhythmia ☻check apical pulse ♥do not give if HR <60 |
atenolol Prototype Drug | ☺beta1-adrenergic blocker ☻CI: bradycardia, heart block >1st degree, cardiogenic shock, pulm edema, acute bronchospasm, uncompensated cardiac failure, pregnancy, lactation ♥used to tx angina, HTN, MI, HF, ♣s/e: drowsiness, dizziness, syncope, depression, alopecia, weakness, n/v/d, cool extremities, impotence, ↓libido a/e: bradycarida, HoTN, HF, masking of hypoglycemia, bronchospasm, pulm edema, dysrhythmias, thrombocytopenia |