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Top 200 #2
Brand | Generic | Class | Indications | Route/Dose Form | Adult/Ped. Dosing | MOA |
---|---|---|---|---|---|---|
Aciphex | Rabeprazole | PPI (proton pump inhibitor) | GERD, Duodenal Ulcer Disease | Oral; Tablet: 20mg | ADULT: 20-60mg QD-BID PED: 1-11YO: 5-10mg QD 12YO+: 20mg QD | Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells |
Dexilant | Dexlansoprazole | PPI (proton pump inhibitor) | Esophagitis, GERD, Pyrosis (heartburn) | Oral; Delayed-release capsule: 30 or 60mg | ADULT: 30-60mg QD PED: N/A | Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells |
Nexium | Esomeprazole | PPI (proton pump inhibitor) | GERD, Duodenal Ulcer Disease, Gastric Ulcer | Oral, IV; Delayed-release Caps: 20 or 40mg Delayed-release powder for susp: 2.5, 5, 10, 20, 40mg Powder for inj: 20 or 40mg | ADULT: 20-40mg QD PED: 1mo-1YO: 0.5mg/kg QD 1-17YO: 10-20mg QD for 8 wks | Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells |
Prevacid | Lansoprazole | PPI (proton pump inhibitor) | Duodenal Ulcer Disease, Gastric Ulcer, Esophagitis, GERD | Oral; Tablets or Solutabs: 15 or 30mg | ADULT: 15-30mg QD PED: 1-17YO: 15-30mg QD | Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells |
Prilosec | Omeprazole | PPI (proton pump inhibitor) | GERD, Duodenal Ulcer Disease, Stress Ulcer, Gastric Ulcer, Esophagitis | Oral; Delayed-release granules for susp: 2.5 or 10mg Delayed-release Caps: 10, 20, 40mg Delayed-release OTC Tab: 20mg | ADULT: 20-40mg QD PED 1-16YO: 5-20mg QD | Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells |
Protonix | Pantoprazole | PPI (proton pump inhibitor) | GERD, Gastric Hypersecretion | Oral, IV; Delayed-release Tab: 20-40mg Delayed-release granules for susp: 40mg Powder for Inj: 40mg | ADULT: 40-80mg QD-BID PED: 5YO+: 20-40mg QD | Suppresses gastric secretion by inhibiting the gastric H+, K+ ATPase at the secretory surface of parietal cells |
Crestor | Rosuvastatin | HMG-CoA Inhibitor | Hyperlipidemia, Hypertriglyceridemia, Atherosclerosis, Hyperlipoproteinemia, Hypercholesterolemia, Prophylaxis | Oral; Tablets: 5, 10, 20, 40mg | ADULT: 5-40mg QD PED: 10-17YO: 5-20mg QD | Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis |
Lipitor | Atorvastatin | HMG-CoA Inhibitor | Hyperlipidemia, Hypertriglyceridemia, Hypercholesterolemia, Prophylaxis | Oral; Tablets: 10, 20, 40, 80mg | ADULT: 10-80mg QD PED: 10-17YO: 10-20mg QD | Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis |
Mevacor | Lovastatin | HMG-CoA Inhibitor | Hypercholesterolemia, Prophylaxis, Arteriosclerosis | Oral; Tablets: 10, 20, 40mg | ADULT: 10-80mg QD PED: 10-17YO: 10-40mg QD w/dinner | Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis |
Pravachol | Pravastatin | HMG-CoA Inhibitor | Hyperlipidemia, Hypercholesterolemia, Prophylaxis | Oral; Tablets: 10, 20, 40, 80mg | ADULT: 40-80mg QD PED: 8-13YO: 20mg QD 13-18YO: 40mg QD | Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis |
Zocor | Simvastatin | HMG-CoA Inhibitor | Hypercholesterolemia, Hypertriglyceridemia, Prophylaxis | Oral; Tablets: 5, 10, 20, 40mg | ADULT: 5-80mg QD PED: 10-17YO: 10-40mg QD | Inhibits the rate-limiting enzyme (HMG-CoA) in cholesterol synthesis |
Vytorin | Ezetimibe/ Simvastatin | COMBO: HMG-CoA Inhibitor & Intestinal Cholesterol Inhibitor | Hyperlipidemia, Hypercholesterolemia | Oral; Tablets: 10/10, 10/20, 10/40, 10/80 | ADULT: Ezetimibe (1st strength): 10mg QD Simvastatin (2nd strength): 10-80mg QD PED: N/A | Simvastatin: HMG-CoA Inhibitor Ezetimibe: Intestinal cholesterol inhibitor |
Zetia | Ezetimibe | Cholesterol Absorption Inhibitor | Hypercholesterolemia, Hyperlipoproteinemia | Oral; Tablet: 10mg | ADULT: 10mg QD PED: 10YO+: 10mg QD | Inhibits absorption of cholesterol at the brush border of the small intestine via the sterol transporter NPC1L1 |
Lovaza | Omega-3 Ethyl Esters | Omega-3 Fatty Acid | Hypertriglyceridemia | Oral; Softgel Capsule: 1g | ADULT: 4g QD (or divided) PED: N/A | Not completely defined |
Niaspan | Niacin | Nicotinic Acid | Hyperlipidemia | Oral; ER Tablets: 500, 750, 1000mg | ADULT: 100-1000mg TID (max of 4500mg/day) PED: 100-250mg QD (divided into 3 doses) | Precise MOA unknown |
Pepcid | Famotidine | Histamine H2 Antagonist | Duodenal Ulcer, Dyspepsia, Esophagitis, Gastric Ulcer, GERD, H. Pylori Eradication, Multiple Endocrine Adenoma Syndrome, Pyrosis, Systemic Mastocytosis, Zollinger-Ellison Syndrome | Oral, IV; Tablets: 20 or 40mg; AC 10mg tablet or gelcap Premixed Inj. Soln.: 10mg/ml, 20mg/50ml Powder For Susp: 40mg/5ml Complete Chew Tab | ADULT: 20-160mg QD or BID PED: 0-16YO: 0.5mg/kg QD or BID | Inhibits the binding of histamine to H2 receptors on the gastric basolateral membrane of parietal cells, reducing basal and nocturnal gastric acid secretions |
Zantac | Ranitidine | Histamine H2 Antagonist | GERD, Duodenal Ulcer Disease, Gastric Ulcer, Indigestion | Oral, IV; Syrup: 75mg/5ml or 150mg/10ml Tablets: 75, 150, 300mg Inj. Soln.: 1mg/ml or 25mg/ml Granules for Soln.: 150mg Effervescent Tab: 25 or 150mg | ADULT: 150-300mg QD or BID IV: 50mg Q6-8hrs PED: 1mo-16YO: 2-4mg/kg/day Oral or IV | Competitive reversible inhibitor of histamine at H2 receptors |
Tricor; Trilipix; Antara | Fenofibrate | Fibric Acid | Hypercholesterolemia, Hypertriglyceridemia | Oral; Tricor: 48 or 145mg tab; 54 or 160mg micronized tab; 67, 134, 200mg micronized cap Trilipix: 45 or 135 DR cap Antara: 43, 87, or 130mg cap | ADULT: 40-160mg QD PED: N/A | Precise MOA unknown; lipid regulating agent |
Welchol | Colesevelam | Bile Acid Sequestrant | Hypercholesterolemia, Hyperlipoproteinemia, Type 2 Diabetes Mellitus | Oral; Tablet: 625mg Powder for Susp: 3.75g 1875mg BID or 3750mg QD | ADULT: 3 tabs BID or 6 tabs QD; 1.875 gram packet BID or 3.75 gram packet QD PED: 10-17YO: 3.75 gram packet QD | Binds with bile acids in the intestine to form an insoluble complex that is eliminated in the feces |
Zofran | Ondansetron | Serotonin Receptor Antagonist, 5-HT3 (Antiemetic) | Chemotherapy, Radiation, Postop induced N/V | Oral, IV, IM; Tablets: 4, 6, 24 mg ODT: 4 or 8mg Inj. Soln.: 2mg/ml or 32mg/50ml in dextrose 5% Oral Soln.: 4mg/5ml | ADULT: 4-8mg up to TID (max 24mg/day) PED: 4-11YO: 4-8mg Q8hrs | Selective 5-HT3 receptor antagonist |