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USMLE
Repro Path 2
| Question | Answer |
|---|---|
| Which CIN is considered carcinoma in situ? | CIN-3 |
| what type of CA is assoc w/ cervix? what is the Cause Of Death in 80% of patients? | Squamous cell CA COD: UREMIA due to local extension to compress ureters |
| Definition: Endometriosis in the myometrium | Adenomyosis |
| MC GYN malignancy what is presenting age range? | Endometrial CA age: 55-65 |
| Dx: Bulky tumor w/ areas of necrosis and hemorrhage, typically arising de novo, may protrude from cervix and bleed | Leiomyosarcoma |
| Ovarian Cyst: distention of unruptured graafian follicle; may be assoc w/ hyperestrinism and endometrial hyperplasia | Follicular cyst |
| Ovarian Cyst: hemorrhage into persistent corpus luteum; mentrual irregularities | Corpus Luteum cyst |
| Ovarian Cyst: bilateral, multiple, due to gonadotropin stimulation; can be assoc w/ choriocarcinoma or hydatidiform moles | Theca-Lutein cyst |
| Ovarian Cyst: blood-containing cyst from ovarian endometriosis; varies w/ mentrual cycle | Chocolate cyst |
| Dx: amenorrhea, infertility, obesity, hirsutism, multiple small follicular cysts what hormone is in excess? | Polycystic Ovarian syndrome Increased LH |
| Dx: frequently bilateral, lined w/ fallopian tube-like epithelium, benign; | Serous Cystadenoma (20% of ovarian tumors) |
| Dx: frequently bilateral, malignant, w/ fallopian tube-like epithelium; 50% of ovarian tumors | Serous Cystadenocarcinoma |
| Dx: multilocular cyst lined by mucus-secreting epithelium; benign | Mucinous Cystadenoma |
| Dx: malignant tumor w/ mucus-secreting epithelium, can rupture producing multiple peritoneal tumor implants that produce mucinous material | Mucinous Cystadenocarcinoma |
| Definition: Rupture of a mucinous tumor that causes multiple peritoneal tumor implants, all producing large quantities of intraperitoneal mucinous material | Pseudomyxoma Peritonei |
| Dx: benign ovarian tumor that resembles Bladder transitional epithelium | Brenner tumor [Brenner = Bladder] |
| Dx: Ovarian tumor w/ bundles of spindle-shaped fibroblasts what cell does it originate from? | Ovarian Fibroma (Thecal cell) |
| Dx: Ovarian fibroma, ascites, hydrothorax | Meigs syndrome |
| Dx: ovarian estrogen-secreting tumor causing precocious puberty in kids or endometrial hyperplasia in adults. name and describe the characteristic cell | Granulosa cell tumor Call-Exner bodies: small follicles filled w/ eosinophilic secretions |
| Dx: MC malignant germ cell tumor of the ovary; sheets of uniform cells w/ Inc hCG | Dysgerminoma (Seminoma in man) |
| Dx: aggressive malignancy in ovaries, produces alpha-fetoprotein, Schiller-Duval bodies | Endodermal Sinus (Yolk Sac) tumor |
| Dx: rare, malignant ovarian tumor that can develop during pregnancy in mother or baby; large hyperchromatic syncytiotrophoblastic cells; high b-hCG | Choriocarcinoma |
| MC benign ovarian tumor name and describe what it can contain? | Teratoma Stuma Ovarii - functional thyroid tissue |
| In females, how does the Immature vs Mature teratoma differ from Males? | Females: Immature - aggressively Malignant Mature - Benign (Men Mature are Malignant) |
| MC testicular CA in older men | Testicular lymphoma |
| Dx: aggressive malignant neoplasm w/ Inc hCG and early spread to lungs; preceded by hydatidiform mole, abortion of ectopic or normal pregnancy | Gestational Choriocarcinoma (more common then Ovarian type) |
| MC disorder of the breast b/t 25 - 50 yo It may present w/ what characteristic? | Fibrocystic Dz (Blue dome cyst) |
| Dx: diffuse breast pain w/ fibrosis and multiple lesions bilaterally what type has cellular atypia of small ducts w/ fibrosis? | Fibrocystic Dz (Sclerosing Adenosis) |
| MC benign breast tumor in women < 25 yo | Fibroadenoma |
| Dx: small, benign, firm, rubbery, painless, well-circuscribed lesion of breast | Fibroadenoma (less then 25 yo) |
| Dx: benign large bulky mass of connective tissue and cysts in breast; has "leaflike" projections | Cystosarcoma Phyllodes |
| Dx: tumor of lactiferous duct, presenting w/ serous or bloody nipple discharge | Intraductal papilloma |
| What receptors are expressed in post-menopausal malignant CA of breast? (2) | Overexpression of E2/P4 receptors erb-B2 (HER-2) |
| MC place for Malignant breast CA | Upper, outer quadrant |
| Dx: eczematous patches on nipple, characteristic large cells surrounded by clear halo area, invades epidermis, underlying ductal CA always present | Padget Dz of the Breast |
| Dx: malignant breast CA w/ Lymphocytic infiltrate | Medullary CA |
| Dx: multicentric or Bilateral breast CA w/ cells arranged in linear ("indian-file") fashion | Invasive Lobular CA [Invasive Lobular = Indian Line] |
| Dx: breast CA w/ lymphatic involvement of skin by underlying CA causing red, swollen and hot area on breast | Inflammatory CA |
| Dx: tumor cells fill breast ducts resulting in necrosis and a cheese-like consistency (2 names) | Intraductal CA in situ (Comedocarcinoma) [Cheesy Comedian] |
| Dx: malignant breast CA w/ tumor cells in cords, islands and glands embedded in dense fibrous stroma; firm consistency | Invasive Ductal CA (MC malignant Breast CA) |
| Dx: clusters of neoplastic cells fill intralobular ductules and acini and don't pass BM, often metastasis to bilateral breast by time of initial Dx | Lobular CA in situ |
| Dx: malignant breast CA w/ pools of extracellular mucus surrounding clusters of tumor cells; gelatinous consistency | Mucinous (Colloid) CA |
| Dx: young adult w/ fever, vomiting and diarrhea, rapid pulse and hypotension, diffuse macular rash | Toxic Shock syndrome (S. aureus) |
| what bug causes PID in combo w/ monoarticular arthritis? | Gonorrhea |
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Asclepius
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