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USMLE

Cell Bio/Histo/Path -5

QuestionAnswer
Gene associated with this tumor: CML oncogene abl (philadelphia chromosome)
Gene associated with this tumor: Burkitt's lymphoma oncogene c-myc
Gene associated with this tumor: Follicular lymphoma oncogene bcl-2 (inhibits apoptosis)
Gene associated with this tumor: Undifferentiated lymphoma oncogene bcl-2 (inhibits apoptosis)
Gene associated with this tumor: Breast carcinoma oncogene erb-B2
Gene associated with this tumor: Ovarian carcinoma oncogene erb-B2
Gene associated with this tumor: Gastric carcinoma oncogene erb-B2
Gene associated with this tumor: Colon carcinoma oncogene ras
Gene associated with this tumor: Lung tumor oncogene L-myc (L for Lung)
Gene associated with this tumor: Neuroblastoma oncogene N-myc (N for neuroblastoma)
Gene associated with this tumor: Multiple Endocrine Neoplasia type I oncogene MEN1 encoding menin on chromosome 11q
Gene associated with this tumor: Multiple Endocrine Neoplasia type II oncogene ret
Gene associated with this tumor: Multiple Endocrine Neoplasia type III oncogene ret
Chromosome and tumor associated with this gene (what type of gene): Rb Tumor suppressor gene on 13q: Retinoblastoma, osteosarcoma
Chromosome and tumor associated with this gene (what type of gene): BRCA1 Tumor suppressor gene on 17q: Breast and ovarian cancer
Chromosome and tumor associated with this gene (what type of gene): BRCA2 Tumor suppressor gene on 13q: Breast and ovarian cancer
Chromosome and tumor associated with this gene (what type of gene): p53 Tumor suppressor gene on 17p: Most human cancers and Li-Fraumeni Syndrome
Chromosome and tumor associated with this gene (what type of gene): p16 Tumor suppressor gene on 9p: Melanoma
Chromosome and tumor associated with this gene (what type of gene): APC Tumor suppressor gene on 5q: Colorectal cancer
Chromosome and tumor associated with this gene (what type of gene): WT1 Tumor suppressor gene on 11q: Wilm's tumor
Chromosome and tumor associated with this gene (what type of gene): NF1 Tumor suppressor gene on 17q: Neurofibromatosis type 1
Chromosome and tumor associated with this gene (what type of gene): NF2 Tumor suppressor gene on 22q: Neurofibromatosis type 2
Chromosome and tumor associated with this gene (what type of gene): DPC Tumor suppressor gene on 18q: Pancreatic cancer
Chromosome and tumor associated with this gene (what type of gene): DCC Tumor suppressor gene on 18q: Colon cancer
Gene and associated tumor on chromosome: 5q Tumor suppressor gene APC: Colorectal cancer
Gene and associated tumor on chromosome: 9p Tumor suppressor gene p16: melanoma
Gene and associated tumor on chromosome: 11q Tumor suppressor gene WT1: Wilm's tumor
Gene and associated tumor on chromosome: 13q Tumor suppressor genes Rb (Retinoblastoma, Osteosarcoma) and BRCA2 (Breast and Ovarian cancer)
Gene and associated tumor on chromosome: 17p Tumor suppressor gene p53: Most human cancers and Li-Fraumeni syndrome
Gene and associated tumor on chromosome: 17q Tumor suppressor genes BRCA1 (Breast and ovarian cancer) and NF1 (Neurofibromatosis type 1)
Gene and associated tumor on chromosome: 18q Tumor suppressor genes DPC (Pancreatic cancer) and DCC (Colon cancer)
Gene and associated tumor on chromosome: 22q Tumor suppressor gene NF2: Neurofibromatosis type 2
Gene and matching chromosome associated with: Retinoblastoma Tumor suppressor gene Rb on chromosome 13q
Gene and matching chromosome associated with: Osteosarcoma Tumor suppressor gene Rb on chromosome 13q
Gene and matching chromosome associated with: Breast cancer Tumor suppressor genes BRCA1 (17q) and BRCA2 (13q)
Gene and matching chromosome associated with: Ovarian cancer Tumor suppressor genes BRCA1 (17q) and BRCA2 (13q)
Gene and matching chromosome associated with: Most human cancers Tumor suppressor gene p53 on chromosome 17p
Gene and matching chromosome associated with: Li-Fraumeni syndrome Tumor suppressor gene p53 on chromosome 17p
Gene and matching chromosome associated with: Melanoma Tumor suppressor gene p16 on chromosome 9p
Gene and matching chromosome associated with: Colorectal cancer Tumor suppressor gene APC on chromosome 5q
Gene and matching chromosome associated with: Wilms' tumor Tumor suppressor gene WT1 on chromosome 11q
Gene and matching chromosome associated with: Neurofibromatosis type 1 Tumor suppressor gene NF1 on chromosome 17q
Gene and matching chromosome associated with: Neurofibromatosis type 2 Tumor suppressor gene NF2 on chromosome 22q
Gene and matching chromosome associated with: Pancreatic cancer Tumor suppressor gene DPC on chromosome 18q
Gene and matching chromosome associated with: Colon cancer Tumor suppressor gene DCC on chromosome 18q
Oncogenes: gain or loss of function QUICK onco: gain
tumor suppressor genes: gain or loss of function QUICK tumor suppressor: loss
Oncogenes: one or two alleles need to be damaged QUICK One (gain of function)
Tumor suppressor genes: one or two alleles need to be damaged QUICK Two (loss of function)
Created by: Asclepius
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