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USMLE
Brain Tumors
| Question | Answer |
|---|---|
| This adult tumor crosses the Corpus Collosum, stains for GFAP, and has tumor cells bordering areas of necrosis and hemorrhage on Light microscopy | Glioblastoma Multiforme (Grade IV Astrocytoma) |
| This adult tumor has concentric arranged calcifications, and arises from arachnoid cells external to the brain. | Meningioma |
| This adult tumor is S-100 Positive, and commonly occurs in the cerebellar pontine angle, bilaterally in neurofibromatosis 2 (chromosome 22) | Schwannoma |
| This adult tumor is often in the frontal lobes, and has round nuclei with clear cytoplasm that is often calcified. You may see a chicken wire capillary pattern | Oligodendroma |
| This Adult Tumor is often prolactin secreting, causes bitemporal hemianopsia, what is its origin? | Rathke's Pouch (its a pituitary adenoma) |
| This childhood tumor is well circumscribed and contains eosinophilic corkscrew fibers. | Pilocytic Astrocytoma. Low grade |
| This childhood tumor is most often in the cerebellum, and contains rosettes or pervivascular pseudorosettes, and can cause hydrocephalus. It is a form of a primintive neuroectoderm tumor | Medulloblastoma. |
| This tumor is often in the 4th ventricle, and has characteristic rod shaped basal ciliary bodies found near the nucleus, as well as pervascular pseudorosettes | Ependyoma |
| This childhood tumor is often in the cerebllum, and contains foamy cells and is rich in vasculature. What chromomome is likely altered and what hematological finding will be present? | Chromosome 3 - Von Hippel Lindau, and you will find polycythemia due to increased EPO. The tumor is a Hemangioblastoma |
| This childhood tumor also causes bitemporial hemianopsia, and has calcifications. What is it derived from? | Rathke's pouch - Craniopharyngioma. |
| Top 5 Childhood brain tumors ordered by descending incidence | 1.) Pilocytic (low grade) astrocytoma 2.) Medulloblastoma 3.) Ependymoma 4.) Hemangioma 5.) Craniopharyngioma |
| Top 5 Adult brain tumors ordered by descending incidence | 1.) GBM (grade IV astrocytoma) 2.) Meningioma 3.) Schwannoma 4.) Oligodendroglioma 5.) Pituitary adenoma |
| Location of most childhood brain tumors | infratentorial |
| Location of most adult brain tumors | supratentorial |
| Half of all adult brain tumors are | metastases |
| Trigger words: Spindle cells, whorled pattern, psammoma bodies | Meningioma |
| Trigger words: Aything associated w/NF 2 | Schwannoma |
| Trigger words: pseudopalisading, butterfly, GFAP stain | Glioblastoma Multiforme |
| Trigger words: fried egg | Oligodendroglioma |
| Trigger words: Rathke's pouch - adult tumor? Rathke's pouch - childhood tumor? | Pituitary adenoma Craniopharyngioma |
| Trigger words: Foamy cells | Hemangioblastoma |
Created by:
Asclepius
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