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USMLE
Rate Limiting Enzymes
Question | Answer |
---|---|
Glycolysis | Phosphofructokinase-1 |
Pyruvate Metabolism | Pyruvate dehydrogenase complex |
TCA cycle | Isocitrate dehydrogenase |
Citric acid cycle | Citrate synthase |
Glycogenesis | Glycogen synthase |
Glycogenolysis | Glycogen phosphorylase |
Gluconeogenesis | Phosphoenolpyruvate carboxykinase & Fructose 1,6-Biphosphotase |
Hexose Monophosphate Shunt | Glucose 6 phosphate dehydrogenase |
Pentose phosphate | Glucose-6-phosphate dehydrogenase |
Cholesterol synthesis | HMG-CoA reductase |
Ketone body synthesis | HMG-CoA lyase |
Fatty acid synthesis | Acetyl CoA carboxylase |
b oxidation of fatty acids | Carnitine acyl transferase [CPT-1] |
Lipogenesis | Acetyl-CoA-carboxylase |
Phospholipid synthesis | Cytidyltransferase |
Sphingolipid synthesis | 3 ketosphiganine synthase |
Eicosanoid synthesis | Phospholipase A2 |
Prostaglandin synthesis | Phospholipase A2 |
Steroidogenesis | CSCC (27 desmolase) |
Heme synthesis | Aminolevulinate synthase |
Bilirubin metabolism | Active transport into bile ducts |
Bile acid synthesis | Colesterol 7a hydroxylase |
DNA synthesis | Ribonucleotide reductase |
Purine synthesis | Glutamine Prp transferase |
Pyrimidine synthesis | Carbamoyl phosphate synthetase II |
Urea cycle | Carbamoyl phosphate synthetase I |
Lipolysis | Hormone sensitive lipase |
Fructose metabolism | Aldolase B |
Galactose metabolism | Galactose 1-Phosphate Uridyltransferase |
Heme Synthesis | ALA synthase |
Heme catabolism | UDP glucoronyl transferase |
Triglyceride synthesis from fatty acids | Glycerol 3-P Dehydrogenase |