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Mr. D Pharmacolgy
Pharm Ch 13 for test on 6/27/2014
| Question | Answer |
|---|---|
| Diazepam | Valium |
| Lorazepam | Ativan |
| Trifluoperazine | Stelazine |
| Chlorpromazine | Thorazine |
| Thioridazine | Melleril |
| Clonazepam | Klonopin |
| Clozapine | Clozaril |
| Risperidone | Risperdal |
| Quetiapine | Seroquel |
| Neuroleptic | Antipsychotic |
| Antipsychotic | Psychotropic |
| Typical 1st generation antipsychotics have been used since the | 1950's |
| Typical 1st generation antipsychotics (mechanism of action) | Blocks Dopamine only (and some Adrenergic receptors) |
| Typical 1st generation antipsychotics relieve what type of symptoms | (+) positive symptoms of schizophrenia |
| Typical 1st generation antipsychotics (side effects) | More side effects than atypical 2nd generation antipsychotics (EPS) |
| Typical 1st generation antipsychotics (addictiveness) | More addicting than atypical 2nd generation antipsychotics |
| Typical 1st generation antipsychotics (current use) | Not used as much anymore |
| Atypical 2nd generation antipsychotics been used since the | 1990's |
| Atypical 2nd generation antipsychotics (mechanism of action) | Blocks dopamine and serotonin |
| Atypical 2nd generation antipsychotics (side effects) | Major Weight Gain. Cause less side affects than typical 1st generation antipsychotics. |
| Atypical 2nd generation antipsychotics (addictiveness) | Less addicting than 1st generation antipsychotics |
| Atypical 2nd generation antipsychotics (current use) | Frequently used |
| Typical 1st generation med classes | Phenothiazines and Butyrophenones |
| Phenothiazine drugs | Clozapine, Thioridazine, Trifluoperazine |
| Butyrophenones drug | Haloperidol |
| Phenothiazines have strong | (AC) anticholinergic effects and (AAB) alpha-adrenergic-blocking effects |
| Phenothiazines block | ACH |
| AC effects caused by phenothiazines | Lowered Parasympathetic Affect: dry mouth, constipation, blurred vision, hypertension, increased pulse rate |
| Alpha adrenergic blocking causes | hypotension |
| Anticholinergic mimics | sympathetic response |
| Will Mr. D try to mix up drug name with drug class? | Yes |
| What is the most important page in chapter 13 according to Mr. D | 177, table 13:1 |
| Clozapine side effects | Impaction(worse than constipation), agranulocytosis |
| Mr. D say Clozapine is an all or nothing drug | When it works its awesome, when not working no good. |
| Clozapine is used as a | last resort |
| Clozapine using patients need | labs(WBC), monitor weight, high fiber, and exercise |
| An antianxiety drug is considered a | Benzodiazepine |
| Name 4 antianxiety (Benzodiazepine) drugs | Lorezepam, Clonazepam, Alprazolam, and Diazepam(#1) |
| Invega drug class | atypical 2nd generation |
| Which neurotransmitters are blocked by Invega? | dopamine and serotonin |
| Extrapyramidal Symptoms (EPS) | Dystonic reactions, Akathisia, and Parkinsonism |
| Dystonic Reactions | muscle spasms, twitching, facial grimacing(torticollis) |
| Akathisia | restlessness, constant body movement |
| Psuedo-Parkinsonism | shuffling gate |
| Akinesia | Not EPS, no movement |
| EPS drugs | Benztropine(1st choice) and Trihexyphenidle(2nd choice) |
| Benztropine and Trihexyphenidle (drug class) | Anticholinergic (Block ACH) |
| EPS is caused by | blocking dopamine receptors in the basal ganglia |
| Dopamine and ACH should always be | balanced |
| Psychotropic meds lower dopamine levels to treat psychosis. If Dopamine levels are lowered than | ACH levels should also be lowered |
| Elderly people already have low levels of | ACH |
| Tardive Dyskinesia | Caused by long term use of antipsychotics. More common with 1st gen meds. Happens when going off med. Only way to stop it is to go back on medication. Permanently Irreversible. Involuntary movements of the tongue, jaw, lips, and extremities. |
| Neuroleptic Malignant Syndrome | Fatal. Not dose related. Sx: diaphoresis, confusion, ANS instability, catatonia, elevated CPK, unstable blood pressure, and fatigue. |
| Treatment for NMS | Stop medication immediately. Do not replace with another med. |
| If I block ACH which division of the ANS is being inhibited? | Parasympathetic |
| If I block ACH what will happen to blood pressure? | increased blood pressure |
| If I block ACH what will happen to pulse rate? | increased pulse |
| Benztropine has the following side effects: | hypertension, tachycardia, decrease secretions, decreased peristalsis |
| Benztropine leads to hypotension. True or False | False |
| Trihexyphenidyl and Benztropine belong in the same family. True or Fasle | True |
| Benztropine has a high | potency |
| Increased triglycerides, weight gain, and diabetes are adverse effects associated with | atypical drugs |
| What are the main goals of antipsychotic drug therapy? | block the D2 receptor and decrease Serotonin |
| Select the adverse effects of atypical antipsychotics. | postural hypotension and weight gain |
| What is the relationship between dopamine and ACH in terms of motor movement? If Dopamine low and ACH high it will result in: | tremors |
Created by:
Sanctus Verus
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