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Lecture 26
White Blood Cells-Innate Immunity
Term | Definition |
---|---|
Cell Types | Leukocytes (white blood cells). 5 types-all have diff defesne func. Multi-lobed nucei granulocytes. Neutrophils, eosinophils, basophils. Stained by neutral,acid, or basic dyes. Single lobbed nuclei agranulocytes: monocytes, lymphocytes. |
Phagocytes | Phagocytosis of bacteria and dead cells. Order of attack: resident macrophages,neutrophils, new monocyte leads to macrophagemigration |
Neutrophils | Rapid response- move from blood to damage tissue. Diapedesis-squeeze through capillary pores attack bacteria. |
Monocytes-Macrophages | Monocytes move into tissues and become macrophages. Rezident macrophages wait for bacteria to come. During infection, vast movement of monocytes into infected area. Massive macrophage attack on bacteria. |
Eosinophils | Produce acids that kill parasites. High in GI tract. Produce allergic responses. |
Basophils | Release histamine. Histamine causes inflammaiton. Inc blood flow (arteriolar dilation). Inc pore size (allows diapedesis). |
Defense Mechanisms | Innate (non specific) immunity. Defense mechanisms not influenced by prior exposure. Acquired (specific) immunity, B and T lymphocytes attack specific antigens. |
Inflammation | Non-specific response. Occurs w/ any infecetion or injury |
Chemotaxis | Chemical signals form damaged areas draw phagocytes |
Complement System | Series of 9 plasma factors-C1-C9. Major bacteria killer |
Activation | By antibodies or by the protein properdin. This is opsinin tagging of surface carbs on bacteria. Leads to pore formation in bacteria membranes. |
Pore Formation | C5-C9 can from pores in membrane.Very local, rapid inactivation. Pore allows osmotic lysis: Na+ enters, H2O follows, cell swells and bursts. Ill feeling cause: bacterial toxins, activation of pain receptors from partially digested protein of dead bacteria |
Histamine | Inc. blood flow-brings phagocytes,oxygen,amino acids. Inc. capillary permeability-opens pores for liquid and diapedisis. |
Interferon | Cytokine-released from virus-infected cells. Activate anti-viral defenses in cells near viral infected cells. Many side affects. |
Natural Killer Cells | Non t-cell lymphocytes. No prior exposure needed for activation |
Activation | Lipids and carbs on bacteria, tumors, transplants, and by antibodies on cell surface. Forms pores by injecting perforin-kills by lysis. |