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Anemia
Hematology and Coagulation
Term | Definition |
---|---|
Acute Blood Loss Anemia | Result of a traumatic condition Severe hemorrhage Body adjusts to the lower blood volume by diverting fluids from other extra-vascular spaces to the circulation |
Acute Blood Loss Anemia Lab Finding | Rapid decrease of platelet levels Left shift of the leukocytes (immature cells) Direct smear: normocytic, normochromic cells. |
Chronic Blood Loss Anemia | Blood loss of small amounts occurs over an extended period of time Chronic and continual loss of blood - Overall blood volume is not effected Usually results in an iron deficiency anemia - Depleted iron stores |
Clinical findings Chronic Blood Loss Anemia | Reticulocytes - Normal or slightly elevated Anemia develops after iron storage is depleted - hypochromic, microcytic WBCs - Normal or slightly decreased Platelets - Normal and decrease in severe iron deficiency |
Aplastic Anemia | Failure of pluripotential stem cells to produce RC, WC, and megakaryocytes CD 34 cell population is deficient in number Results in reduced growth and production of all blood cell lines |
Forms of Aplastic Anemnia | Idiopathic Constitutional Iatrogenic- drug related Infections |
Lab Finding of Aplastic Anemia RBC's | Normocytic, normochromic Variations of aniso, poik and macro |
Lab Finding of Aplastic Anemia Pancytopenia | Deficient production of blood cells of all types Diagnosis is made when at least 2 of 3 peripheral blood values fall below critical levels. |
Fanconi’s Anemia | Inherited through an autosomal recessive gene Most frequently seen aplastic anemia in children Twice as common in males than females |
Fanconi's Anemia Clinical Symproms | Low birth weight Skin hyperpigmentation Short stature Skeletal disorders |
Falconi's Anemia Lab Finding | Progressive pancytopenia-Apparent by 5 years old Hemoglobin level:5-6 g/dl with moderate to severe pancytopenia DNA testing using HLA typing |
Pure Red Cell Aplasia | involves disturbed erythropoeisis |
Pure Red Cell Aplasia Acquired | Selective failure of RBC production Leukocytes and platelets are normal |
Pure Red Cell Aplasia Chronic | Associated with drugs, collagen vascular disorders and lympho-proliferative disorders |
Diamond-Blackfan Syndrome | Congenital hypoplastic anemia Slow progressive and refractory anemia Normal WBCs and platelets Severe cases RBCs are normochromic, Slight Macrocytic |
Transient Erythroblastopenia of Childhood | Occurs in healthy children younger than 8 years old Self-limiting - Previous viral infection common |
Transient Erythroblastopenia of Childhood Clinical Findings | Moderate to severe normocytic anemia Severe reticulocytopenia |
Congenital Dyserythropoietic Anemia | Indirect hyperbilirubinemia Ineffective erythropoiesis Peculiarly shaped multinuclear erythroblasts |
Congenital Dyserythropoietic Anemia Laboratory Findings | Decreased Hgb, Hct, and RBC's Decreased leukocytes and platelets |