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Pharm - Lipids

Pharmacology - Hyperlipidemia

QuestionAnswer
Bile Salt Seqeustrants Decrease cholesterol absorption Decrease Total cholesterol and LDL, Increase VLDL MOA: bind bile acids in the intestinal lumen, inhibiting reuptake and causing fecal excretion
Bile Salt Seqeustrants - Contraindications and Adverse Drug Reactions Contr: complete biliary obstruction ADR: Constipation, abdominal pain, flatulence, chest pain, HA, burnt odor to urine, angina
Cholestyramine Questran - powder - Bile Salt Seqeustrant
Colestipol Colestid - tab or powder - Bile Salt Seqeustrant
Colesevelum Welchol - tab - Bile Salt Seqeustrant
HMG-CoA Reductase Inhibitors (AKA: Statins) Inhibit HMG-CoA reductase (the rate limiting enzyme in cholesterol synthesis) Decrease LDL and total cholesterol
HMG-CoA Reductase Inhibitors (AKA: Statins) - Contraindications and Monitoring Pregnancy Category X Contr: Active liver disease, pregnancy, lactation Monitor: LFTs baseline, and at 12 weeks then every 6 months
HMG-CoA Reductase Inhibitors (AKA: Statins) - Adverse Drug Reactions ADR: Rhabdomyolysis, HA, stomach pain Drug interactions: increases effect/toxicity of levothyroxine Concurrent use with erythromycin may increase risk of rhabdomyolysis
Simvastatin Zocor - HMG-CoA Reductase Inhibitor (AKA: Statin)
Pravastatin Pravachol - HMG-CoA Reductase Inhibitor (AKA: Statin)
Lovastatin Mevacor - HMG-CoA Reductase Inhibitor (AKA: Statin)
Atorvastatin Lipitor - HMG-CoA Reductase Inhibitor (AKA: Statin)
Fluvastatin Lescol, Lescol XL - HMG-CoA Reductase Inhibitor (AKA: Statin)
Rosuvastatin Crestor - HMG-CoA Reductase Inhibitor (AKA: Statin)
Fibric Acid Derivatives Decrease total cholesterol, VLDL, and triglycerides Increase HDL
Fibric Acid Derivatives - Contraindications and Adverse Drug Reactions Pregnancy category B (Lopid), C (Tricor) Contr: renal or hepatic dysfunction, gall bladder disease ADR: increase hypoprothrombinemic effects with warfarin
Gemfibozil Lopid - Fibric Acid Derivative Take 30 minutes before breakfast and dinner Pregnancy category B
Fenofibrate Tricor - Fibric Acid Derivative; Take with food Pregnancy category C
Nicotinic Acids Decrease total cholesterol, LDL, and VLDL; Increase HDL MOA: inhibits the synthesis of VLDL
Nicotinic Acids - Contraindications Pregnancy category A (= good) Contr: liver disease, peptic ulcer, severe hypotension
Nicotinic Acids - Adverse Drug Reactions ADR: HA, nausea, bloating, jaundice, sensation of warmth generalized flushing (can decrease with ASA) Drug interactions: decrease effects of oral hypoglycemics
Niacin Nicotinic Acid - Controlled release and immediate release (Less flushing with controlled release)
Ezetimibe - MOA Zetia MOA: selectively inhibits the intestinal absorption of cholesterol
Ezetimibe - Contraindications and ADRs Zetia Adverse effects: back pain, arthralgia, fatigue Contraindications: moderate to severe hepatic disease Drug interactions: cyclosporine
Vytorin is combination of what? Ezetimibe (Zetia) + Simvastatin (Zocor)
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Created by: Marywood
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