Busy. Please wait.

Forgot Password?

Don't have an account?  Sign up 

show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.

By signing up, I agree to StudyStack's Terms of Service and Privacy Policy.

Already a StudyStack user? Log In

Reset Password
Enter the email address associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know (0)
Know (0)
remaining cards (0)
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Transplantation Imm.

Transplantation Immunology

Rejection occurs due to ? * immune recognition and response to foreign histocompatibility antigens
most important antigens of rejection ? MHC..... * but there are others, so can still reject if all MHCs all line up perfectly
What is the normal role of HLA antigens in the immune response? * Present antigenic peptides to T cells
HLA class 1 = ? * HLA - A, B, C.... * also expresses B2-microglobulin.... * All are in MHC-I
HLA class 2 = ? * All in MHC-II.... * are HLA - DR (a/b), DP (a/b), and DQ (a/b)
How many different HLA molecules are on the cell? * you have both on each cell
expression of alleles of HLA ? * get codominance with Haplotype inheritance of MHC antigens.... * each person has 2 different halotypes for each HLA bc of two parents, but are codominantly expressed
Hyperacute Rejection ? * happens in minutes-hrs and is from anti-donor ABs and complement
Acute Rejection ? * days-weeks and is from cell mediated and humoral .... * primary activation of immune system and T-Cells recognize foreign HLA antigens.... * if Cd4+ is seen, then complement and Ab also mediates this
Chronic Rejection ? * time frame is months-years and MOA is unclear
One of the top drugs for anti-rejection ? * cyclosporine - but have to ween off c it can cause kidney issues
Testing for Donor-Recipient Compatibility in Transplantation ? * 1. ABO Blood typing -- 2. HLA identification (tissue typing) -- 3. Antibody Screening (reactive with HLA) -- 4. Genotyping with PCR and other molecular techniques -- 5. Crossmatching – see if recipient has preformed Abs against donor
Why have we been using more pig transplants ? * lack of human cadaver parts
Hematopoietic Stem Cell Transplantation (HSCT) use and marker for them in the blood ? * Used to treat malignancy, immunodeficiency, bone marrow defects, autoimmunity ..... * CD34 marker
Graft-versus-host disease ? * complication of allogeneic HSCT is graft-versus-host disease (GvHD) ..... * GvHD is caused by mature donor T cells contaminating the HSC inoculum, which can recognize HLA
How to help GVHD ? * help eliminate as many as those mature T-cells as possible, bc once activated, it is pretty much impossible to stop
Acute GVHD = ? * about 3 weeks
Chronic GVHD = ? * months
Helps GVHD a lot ? * matching of the HLA antigens
Created by: thamrick800