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SB82 Spleen

SB82 Spleen - loosely taken from Fiser's ABSITE review

QuestionAnswer
Which organ is the largest producer of IgM? __________ Spleen
What comprises Howell-Jolly bodies? __________ Nuclear remnants
What comprises Heinz bodies? __________ Hemoglobin
What is the definition of culling? Removal of less deformable RBCs
What is the main site of clearance of bacteria that do not have pre-existing antibodies? ___________ Spleen
Which opsonin that facilitates phagocytosis is produced in the spleen? ___________ Tuftsin
Which substance produced in the spleen activated the alternate complement pathway? _______________ Properdin
Accessory spleens are most commonly found in this location Splenic hilum (20%)
Pathophysiology of ITP IgG antiplatelet antibodies bind platelets, causing thrombocytopenia
Therapy for ITP Steroids (primary therapy), plasmapheresis, gammaglobulin, splenectomy
What percentage of patients with ITP respond to splenectomy? 80%
When should you give platelets prior to splenectomy for ITP? One hour before surgery
What is the pathophysiology of TTP? Loss of platelet inhibition causes thrombosis and infarction with profound thrombocytopenia
What percent of patients with TTP respond to medical therapy? 80%
What is the treatment of TTP? Plasmapheresis (primary); steroids, aspiring
Post-splenectomy sepsis is highest in patients who required splenectomy for what conditions? Hemolytic disorders or malignancy
Most episodes of post-splenectomy sepsis occur within what time frame? Within 2 years of splenectomy
Post-splenectomy changes in blood studies Increased RBCs, increased WBCs, increased platelets
What is the most common benign splenic tumor? ___________ Hemangioma
What is the indication for resection of splenic hemangioma? Symptomatic
What is the most common malignant splenic tumor? ___________ Non-Hodgkin’s lymphoma
When should you perform surgery for splenic cysts? If they become symptomatic or are > 10 cm
This syndrome is characterized by rheumatoid arthritis, hepatomegaly, splenomegaly _________ Felty’s syndrome
This lipid disorder leads to splenomegaly __________ Gaucher’s disease
What is the most common congenital hemolytic anemia requiring splenectomy? _________ Spherocytosis
What is the mutated protein causing spherocytosis? __________ Spectrin
Why do you perform cholecystectomy with splenectomy in patients > 5 yo with spherocytosis? It causes pigmented gallstones
Protein mutations in elliptocytosis ___________ Spectrin and protein 4.1
Definition of Stage I Hodgkin’s lymphoma 1 area or 2 contiguous areas on the same side of the diaphragm
Definition of Stage II Hodgkin’s lymphoma 2 non-contiguous areas on the same side of the diaphragm
Definition of Stage I Hodgkin’s lymphoma Involved on each side of the diaphragm
Definition of Stage I Hodgkin’s lymphoma Involves any non-lymphoid tissue (other than the spleen)
Most common form of Hodgkin’s lymphoma _________ Nodular sclerosing
Treatment for hairy cell leukemia Splenectomy and interferon-gamma
Splenosis is usually related to this event ___________ Trauma
The most common cause of splenic artery or splenic vein thrombosis __________ Pancreatitis
Most common cause of splenic artery aneurysms __________ Fibromuscular dysplasia or atherosclerosis
Created by: StudyBug82 on 2014-01-19



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