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Nutrition
First Aid - Biochem - Nutrition
Question | Answer |
---|---|
Fat Soluble vitamins | A, D, E, K absorption dependent on gut(ileum) and pancreas, toxicity more common than for water-soluble b/c they accumulate in fat > malabsorption dz. = CF can cause fat soluble vitamin deficiencies |
Water soluble vitamins | B1-B7, B12, C, Biotin, Folate - all wash out easily from body except B12 and folate(stored in the liver), B-complex deficiencies often result in dermatitis, glossitis, and diarrhea |
Vitamin A (retinol) - function | antioxidant, part of visual pigments, nml differentiation of epithelial cells to specialized tissues (pancreatic cells and mucus secreting cells), used topically for acne and wrinkles, found in liver and leafy vegetables |
Vit. A deficiency | night blindness and dry skin |
Vit. A overdose | arthralgias, fatigue, headache, skin change, sore throat, alopecia, teratogenic(cleft palate and cardiac abnml.) pregnancy test before isoretinoin (can treat measles) |
Vit. B1 (thiamine) - function | in thiamine pyrophosphate (TPP) a cofactor for enzymes, pyruvate dehydrogenase (glycolysis), alpha-ketoglutarate DH (TCA), transketolase (HMP shunt), and branched chain AA dehydrogenase |
Vit. B1 (thiamine) - deficiency | impaired glucose breakdown > ATP depletion, highly aerobic tissues(brain and heart) affected first > wenickes (ataxia, confusion) and beri beri (muscle waste, cardiac failure), malnutrition, alcoholism |
Vit. B2 (riboflavin) - function and deficiency | cofactor in oxidation and reduction (FADH2) (FAD and FMN are derived from riboflavin) - cheilosis (inflammation of lips, scaling and fissures at corners of mouth) or corneal vascularization |
Vit. B3 (niacin) - function | part of NAD+, NADP+, made from tryptophan, syn. requires B6 |
Vit. B3 (niacin) - deficiency | D's of pellagra = diarrhea, dermatitis, dementia. Glossitis. pellagra. decreased vit. B6. |
Vit. B3 (niacin) - overdose | facial flushing due to pharmalogic doses from tx. of hyperlipidemia > excess untreated corn in diet can cause pellagra (b/c untreated B3 in corn not absorbable) |
Vit. B5 (pantothenate) - function and deficiency | essential part of CoA (cofactor for acyl transfers) and fatty acid syn., deficiency = dermatitis, enteritis, alopecia, adrenal insufficiency |
Vit. B6 (pyridoxine) - function | converted to pyridoxal phosphate, cofactor in transamination (ALT/AST) decarboxylation rxns. glycogen phosphorylase, cystathionine syn. and heme syn. needed for syn. of B3 (niacin) from tryptophan |
Vit. B6 (pyridoxine) - deficiency | convulsions, hyperirritability, peripheral neuropathy (deficiency inducible by INH and oral contraceptives), and sideroblastic anemia |