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Heme review no onc
Clinical Medicine
Question | Answer |
---|---|
Jak2 mutation is seen in | polycythemia Vera (70%) |
Post bath pruritus occurs with | polycythemia Vera* |
Tear-drop shaped RBC’s on peripheral smear | Myelofibrosis* |
Most common leukemia is | CLL* |
Smudge cells (damaged lymphocytes) on peripheral smear | CLL* |
BCR-ABL gene mutation on peripheral blood is diagnostic of | CML* |
Philadelphia chromosome is diagnostic of | CML* |
Blasts are seen in these types of leukemias | acute leukemias |
leukemias Primarily in children | ALL |
leukemias Primarily in adults | AML |
Auer Rods occur in | Acute myelogenous leukemia (AML)* |
"Painless lymphadenopathy, think" | lymphoma |
B symptoms of cancer include | "Fever, night sweats, weight loss, fatigue" |
Reed-Sternberg’s cell occur in | Hodgkin’s lymphoma* |
most common Hodgkin’s Lymphoma is | Nodular sclerosing |
found in 40-50% of cases of Hodgkin’s Lymphoma | EBV |
Lymph node pain after ingestion of alcohol think of | Hodgkin’s Lymphoma |
"Lytic lesions on bones, pathologic fractures, hypercalcemia" | Multiple Myeloma* |
Rouleaux formation on peripheral blood smears | Multiple Myeloma |
M-spike on electrophoresis | Multiple Myeloma |
Bence –Jones proteins occur in | Multiple Myeloma* |
Multiple Myeloma do this | Skeletal survey (not a Bone scan)* |
classic triad for Multiple Myeloma | "Plasmacytosis, lytic bone lesions, serum/urine M-protein*" |
Classic hemophilia (Hemophilia A) is due to a deficiency of which clotting factor: | VIII* |
"In a patient with increased platelets and white blood cells, splenomegaly, and an increased red blood cell mass, you would suspect" | polycythemia vera* |
failure to maintain hemostasis | Hemorrhage |
failure to maintain fluidity | Thrombosis |
collective term for all physiologic mechanisms the body uses to protect itself from blood loss | Hemostasis |
Intrinsic pathway is evaluated by | PTT |
Extrinsic pathway factors include | Factor 7 |
Extrinsic pathway is evaluated by | PT |
Common pathway is evaluated by | PT & PTT |
most common congenital disorder of hemostasis | von Willebrand's disease* |
von Willebrand's disease is what type of genetic disorder | autosomal dominant |
This factor mediates platelet adhesion | von Willebrand factor (vWF) |
Treatment for von Willebrand's disease | DDAVP (Desmopressin acetate) or vWF-containing Factor VIII concentrate |
ITP stands for | idiopathic thrombocytopenia purpura |
HIT stands for | heparin induced thrombocytopenia |
TTP stands for | thrombotic thrombocytopenia purpura |
Most common drug induced coagulation disorder | Heparin induced thrombocytopenia |
Microangiopathic hemolytic anemia & thrombocytopenia without an identifiable cause | Thrombotic thrombocytopenic purpura |
Treatment for Thrombotic thrombocytopenic purpura | Plasmapheresis + IV fresh frozen plasma infusion |
"anemia with schistocytes, thrombocytopenia & renal dysfunction in the absence of other causes of coagulopathy" | Hemolytic Uremic Syndrome* |
Most common finding in Hemolytic Uremic Syndrome | Renal failure & thrombocytopenia* |
distinguish DIC from HUS | DIC would have decreased Fibrinogen levels |
With HUS do not give | "Antibiotics, platelet transfusion or nephrotoxic drugs" |
Primary lesion of DIC is | clot formation |
Bleeding & thrombosis co-exist in this clotting disorder | DIC |
Subacute DIC in cancer pts – throwing small clots- DVTs | Trousseau’s syndrome* |
Most common severe bleeding disorder | Hemophilia A* |
Hemophilia A is what type of genetic disorder | "X linked inheritance, only males are affected*" |
Treat hemophilia A with | "Factor VIII replacement, DDAVP for mild disease" |
Christmas Disease | Hemophilia B* |
Hemophilia B is what type of genetic disorder | "X linked recessive, only males affected (more rare than hemophilia A)" |
Treat hemophilia B with | Factor IX concentrates (avoid DDAVP and asprin) |
Factor IX deficiency | Hemophilia B* |
Factor XI Deficiency | Hemophilia C* |
Hemophilia C is seen what type of genetic disorder and seen in what race | Autosomal recessive (affects males and females equally) & seen in Ashkenazi Jews |
Treat Hemophilia C with | FFP (fresh frozen plasma) PRN |
site of synthesis of all coagulation factors except factor VIII | Liver* |
Liver is the site of synthesis of all coagulation factors except | factor VIII |
These are considered “natural anticoagulants” | Proteins C & S |
Diagnosis for Vitamin K deficiency only shows | "5 is normal, 7 is low" |
Diagnosis for Liver disease only shows | both 5 & 7 are low |
What is the most common causes of hereditary hemophilia? | Hemophilia A |
Define Antithrombin III deficiency | Deficiency allows unopposed conversion of fibrinogen to fibrin |
Coagulation disorder that presents with spontaneous thrombo-embolic events (mainly venous) | Antithrombin III deficiency |
Virchow’s Triad is | Vascular damage; Hypercoagulability and Circulatory stasis* |
Polycythemia Vera Treatment includes | Therapeutic Phlebotomy |
Chronic and progressive fibrosis of the bone marrow leading to marrow failure | Myelofibrosis |
what is the only curative treatment of Myelodysplastic Syndrome | Allogeneic transplant |
Describe Chronic Lymphocytic Leukemia | Clonal proliferation of B-cell lymphocytes |
What are smudge cells | damaged lymphocytes* |
Myeloproliferative disease of bone marrow stem cells resulting in unregulated growth of granulocytes | Chronic Myelogeneous Leukemia (CML) |
It is the only known curative treatment for CML | Allogeneic Transplant |
Characterized by unrestrained growth of leukocytes and leukocyte precursors (blasts) in the tissues. | Acute leukemias |
"clumps of myeloblasts, seen in AML" | Auer rods |
Heterogeneous group of cancers that arise from lymphocytes | Non-Hodgkin’s Lymphoma |
"Diffuse or isolated, painless, lymphadenopathy" | Non-Hodgkin’s Lymphoma |
This disease refers to a group of cancers characterized by enlargement of lymphoid tissue | Hodgkin’s Disease |
"Painless cervical, supraclavicular, and mediastinal adenopathy" | Hodgkin’s Disease |
Malignancy of plasma cells which leads to progressive bone marrow failure and infiltration of bone. | Multiple Myeloma |
"These may be present in bones thus predisposing patients to bone pain, pathologic fractures, and hypercalcemia." | Lytic lesions |
BRCA genes are associated with | Breast and ovarian cancer* |
Positive direct coombs test | Autoimmune hemolysis |
Tear-drop shaped RBC’s on peripheral smear | Myelofibrosis |
MCC of anemia in kids | Iron deficiency* |
Pica is common with | Iron deficiency* |
"Decreased platelet count in an otherwise healthy child, oven after a viral infection, think" | ITP |
Most common solid tumor outside the CNS in peds | Neuroblastoma (abdominal tumor)* |
In macrocytic anemia the MCV is | Greater than 100* |
Hemolytic disease of the newborn/ fetal hydrops | Erythroblastosis fetalis |
Most frequent cause of anemia in cancer patients | Inadequate erythropoietin |
MCV < 80 | Microcytic anemia |
MCV > 100 | Macrocytic anemia |
Microcytic anemias include | "Iron deficiency, thalassemia & anemia of chronic disease" |
Target cells are seen in | all anemias |
Macrocytic anemias include | Vitamin B 12 deficiency & folate deficiency |
Anemia that presents with paresthesias early then gait disturbances | Vitamin B 12 deficiency |
ITP is most common in what age group | Childhood |
Failure of all cell lines suggest | Aplastic anemia |
Poor dietary intake of iron causes | Anemia |
Bence jones proteins | Multiple myeloma |
Earliest and best indicator of iron deficiency | Serum ferritin* |
Type of anemia associated with gastric cancer | Pernicious anemia |
Positive schillings test | Vitamin B 12 deficiency |
Heinz bodies are seen in | G6PD deficiency* |
Positive coomb’s test | Autoimmune hemolytic anemia |
Most common inherited bleeding disorder | Von willebrand’s disease* |
Factor VIII | Hemophilia A* |
Factor IX | Hemophilia B / Christmas disease* |
Factor XI | Hemophilia C / Rosenthal syndrome* |
AE of Cisplatin | "Renal impairment, auditory neuropathy" |
AE of adriamycin | Cardiac toxicity |
AE of vincristine | Peripheral neuropathy |
AE of Bleomycin | Pulmonary toxicity |