Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm Autonomic NS

Alpha 2 Agonists: Central

QuestionAnswer
Drugs in this class include clonidine [Catapress], guanabenz [Wytensin] guanfacine [Tenex, Intuniv], methyldopa
central alpha 2 agonists reduce sympathetic tone and increase parasympathetic tone which results in lower BP, bradycardia, peripheral resistance
crosses the blood brain barrier so should be used cautiously in depression, older adults, cerbrovascular disease clonidine, methyldopa
nightmares and insomnia have been associated with clonidine
have been associated with life-threatening rebound HTN mediated by increased SNS activity so should be tapered gradually. This is exacerbated if pt is also taking beta-adrenergic blockers
has been associated with a positive Coombs' test methyldopa
beta blockers and centrally acting alpha2 agonists should not be given together but if they are and one needs to be withdrawn the beta blocker should be tapered first to prevent excessive opposed stimulaton of alpha 2 receptors that can result in a hypertensive crisis in as little as 12 hours
because they lower BP by reducing sympathetic function, they can produce compensatory effect on BP resulting in retention of sodium and expansion of blood volume through mechanisms that are not dependent on adrenergic nerves
for treatment of HTN usually 2nd line, except for methyldopa which is first line in pregnancy
methylodopa and clonidine can be used with a diuretic to address sodium and water rention
combination tablet chlorthalidone[Clorpres], clonidine with thiazide
unlabeled uses of clonidine withdrawal symptoms, ADHD
monitoring during tx with methyldopa Coombs' test before and at 6-12 months after initiation of therapy
methyldopa adverse reactions jaundice (hepatotoxicity), weakness [amemia], urine left standing may darken or turn red/black [not hematuria]
Created by: heatherbrown2020
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards