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Microbio: Prions

USMLE Step 1

BugPathology
Kuru spongiform encephalopathy,trembling disease,rigid limbs,pathologic bursts of laughter,terminal=placcidity & muteness,death w/in 3-12 mons 2ndary 2 decubitus ulcers or pneumonia,due to cannibalism of human brains
Creutzfeld-Jakob Disease (CJD), note spongiform encephalopathy, 10% autosomal dominant rapid progressive dementia,sxs:memory deficits,ataxia,rigidity,40-60 yoa,terminal marked by akinesia & muteness,death w/in 3-12 mons due 2 complicating pneumonia,acquired via tissue transplants,human GH,intracerebral electrode placement,melatonin tab
Scrapie spongiform encephalopathy,ataxia,memory impairment,a disease of sheep,contained w/in sheep brains
Variant Creutzfeld-Jakob Disease (vCJD) aka Mad Cow Disease-note in which animal acts aggressive, ataxic then dies spongiform encephalopathy,similar 2 CJD,broader age range including 20s,human form of Bovine SE,occurs in cattle,due 2 ingestion of food prods contaminated w/ beef/sheep CNS or contaminated directly w/ beef CNS during butchering process,can be asxtic
Fatal Familial Insomnia spongiform encephalopathy,sxs:insomnia,dysautonomia (disease or malfunction of the autonomic nervous system),dementia,then death,is hereditary
Gerstmann-Straussler-Scheinker spongiform encephalopathy,sxs:spastic paresis (progressive unilateral or bilateral hyperextension of the limbs) & ataxia
Created by: jerrica_08
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