click below
click below
Normal Size Small Size show me how
Sulfonylureas
USMLE Step 1
Drug | MOA & ADRs |
---|---|
Tolbutamide | MOA: + insulin secretion, - K channels, increase intracellular Ca, duration is 8 hrs; ADRs: contraindicated in pts w/ liver or kidney failure, accumulation causes hypoglycemia, tightly bound to albumin |
Glyburide | MOA: + insulin secretion, - K channels, increase intracellular Ca, duration is 20 hrs (most potent); ADRs: contraindicated in pts w/ liver or kidney failure, accumulation causes hypoglycemia, tightly bound to albumin |
Glipizide | MOA: + insulin secretion, - K channels, increase intracellular Ca, duration is 20 hrs (most potent); ADRs: contraindicated in pts w/ liver or kidney failure, accumulation causes hypoglycemia, tightly bound to albumin |
Chlorpropamide | MOA: + insulin secretion, - K channels, increase intracellular Ca, duration is 48 hrs; ADRs: contraindicated in pts w/ liver or kidney failure, accumulation causes hypoglycemia esp this drug, tightly bound to albumin |