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Anti-psychotics

USMLE Step 1

DrugMOA & ADRs
Chlorpromazine MOA:phenothiazine that blocks DA receptors in the brain and periphery,also - Ch (muscarinic)/alpha-adrenergic/H1 receptors, rarely used due to its intense ADRs;ADRs:extrapyramidal sxs,tardive dyskinesia,neuroleptic malignant syndome
Fluphenazine MOA:most potent block DA receptors in the brain & the periphery that has less anti-ACh effects;ADRs:increased extrapyramidal effects,tardive dyskinesia,neuroleptic malignant syndome
Haloperidol MOA:most potent butyrophenone that blocks DA receptors in the brain & periphery,has little adrenergic or muscarinic activity;ADRs:extrapyramidal effects are high,tardive dyskinesia,neuroleptic malignant syndome
Droperidol MOA:butyrophenone that blocks DA receptors in the brain & periphery,has little adrenergic or muscarinic activity;ADRs:extrapyramidal effects are high,tardive dyskinesia,neuroleptic malignant syndome
Clozapine MOA:block DA receptors in brain & periphery as well as 5-HT,reserved 4 severe disease b/c its so toxic,fewer extra pyramidal effects carries lower risk of tardive dyskinesia;ADRs:bone marrow suppression,extrapyramidal sxs,neuroleptic malignant syndrome
Risperidone MOA: block DA receptors in the brain & periphery as well as 5-HT,atypical antipsychotic,one of common 1st line drugs for the tx of psychosis;ADRs:extrapyramidal sxs,tardive dyskinesia,neuroleptic malignant syndome
Antipsychotics Uses:antiemetic b/c - D2 receptors in medulla,tranquilizers;ADRs:antimuscarinic cause blurred vision,xerostomia,sedation,confusion,constipation & urinary retention,also cause orthostatic hypoTN,poikilothermia,increased prolactin release,some tolerance
Created by: jerrica_08
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