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Inflam Disorder Drug

USMLE Step 1

DrugMOA & ADRs
Gold, i.e. Auranofin MOA: - macrophages 2 prevent further damage, most effective in RAPIDLY progressive RA-not 4 acute, add when regular NSAIDS fail 2 - inflammation; ADRs: dermatitis, aplastic anemia, contraindicated hepatic or kidney disease & pregnancy, chryiasis, agranulo
D-penicillamine MOA: unknown, used to reduce RF & when gold has failed or is too toxic, chelate heavy metals & tx heavy metal poisoning; ADRs: dermatitis, nephritis, aplastic anemia (bone marrow suppression)
Methotrexate MOA: folic acid antagonist, used when all else has failed; ADRs: bone marrow - (cytopenia, esp leukopenia & megaloblastic anemia), liver failure/cirrhosis, mucosal ulceration & nausea; *Note much lower dose is used than used in cancer tx*
Thalidomide MOA: anti-tumor necrosis factor agents used only for severe inflammatory conditions like leprosy, HIV-assoc skin lesions & multiple myeloma; ADRs: tetratogenic thus women need to have - preggers test or take PO contraceptives prior to taking mediation
Pentoxyfilline MOA: phosphodiesterase - that TNF secretion -, also a platelet aggregator -, limited to use of acute EtOHic hepatitis
Infliximab MOA: monoclonal antibody directed vs TNF, administered in IV form for RA & Crohn's; ADRs: acute onset life threatening sepsis, TB (think about replication in macrophages) and serum sickness (type 3 hypersensitivity)
Etanercept MOA: recombinant TNF receptor binds in bldstream, used subcutaneously, also approved for use w/ RA & ankylosing spondylitis; ADRs: acute onset life-threatening sepsis, increase likelihood for TB, higher incidence to develop multiple sclerosis
Dimercaprol MOA: used for gold overdose
Created by: jerrica_08
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