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Tetracyclines
Stack #127002
| Question | Answer |
|---|---|
| tetracycline | broad spectrum antibiotic affecting a wide range of m/o's |
| tetracycline adverse effects | stains developing teeth-stains are permanet and darken with time-if given to a child 2mos - 7-8 yrs the permanent teeth will be affected...if given prestored in the enamel and dentin of unerupted teeth and are concentrated in the gingival crevicular fluid |
| tetracyclines pharmacokinetics | usually given po, rapid absorption, wide distribution, secreted in saliva and breast milk, concentrated in the liver, excreted into the intestines via the bile |
| tetracycline spectrum | interferes with bacterial protein synthesis-effective against a wide variety of gram- aerobes and anaerobes; bacterial resistance develops slowly, therefor pcn is preferred over tetracycline if there is no allergy-treats ANUG |
| tetracycline-dental uses | drug of choice for certain perio infections but NOT for premed |
| ideal tetracycline therapy | would be delivered directly to the gingival crevice, thereby greatly reducing the systemic dose |
| tetracycline as premed-1 situation | pcn-resistant A.A. organisms have been shown to produce endocarditis. therefore, to prevent endocarditis infection from AA after dental trtmt in patients at risk, a full course (3 wks) should be administered according to the AHA guidelines. |
| tetracyclines adverse rxns | GI: incorporated into calcifying structures, if taken while teeth are being calcified permanent discoloration and enamel hypocalcification can occur. Should not be used in children < 9 yrs old or in pregnant women |
| Minocylcine | can cause black pigmentation of the mandibular and maxillary alveolar bone and the hard palate. when viewed through the mucosa it appears blue |
| tetracyclines: hepatoxicity | liver damage increases with iv use, deaths have occured, esp. in pregnant women, kidney damage is possible |
| tetracyclines: nephrotoxicity | nephrotoxic and should not be used w/ other nephrotoxic drugs |
| tetracyclines: other side effects | hematological effects, candida suprainfections, PHOTOSENSITIVITY, anaphylaxis has occured |
| tetracyclines and dairy | dairy products containing Ca, antacids containing Ca and mineral supplements (Fe, Ca, Zinc) fortified foods, should not be taken within 2 hours of ingesting tetracycline |
| tetracyclines drug interactions | digoxin, lithium, theophylline, oral sulfonylureas, barbituates, phenytoin, BCPS, oral anticoagulants, and other antibiotics |
Created by:
jfgwinn
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