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Cardiac values
normal indicies and drug review
Q | A |
---|---|
CO: | vol/min |
CO= | 4-8 L/min |
CI: | CO/BSA |
CI= | 2.5-5.0 L/min/m2 |
MAP: | [LVP + 2 (RAP)]/3 |
MAP= | 80-100 mmHg |
MPAP: | [RVP + 2 (LAP)]/3 |
MPAP= | 10-20 mmHg |
UO= | 60 mL/hr |
CVP: | RAP, reflecting total vol. |
CVP= | 2-6 mmHg |
PCWP: | LAP=LVEDP |
PCWP= | 4-12 mmHg |
SVR: | [(MAP-CVP)*80]/CO |
SVR= | 900-1400 dynes x s x cm5- |
PVR: | { (PAP-CVP)* 80 } / (CO) |
PVR= | 150-250 dynes x s x cm-5 |
MC RMP= | -80 to -90 mV |
affect of inhibiting Na+ influx into MC: | Phase 0 less steap/high, increased refractory time, decreased HR |
Phase of MC AP involving Mg: | Phase 4 for function of NaK pump restoring ion balence |
SA node rate= | 60-100 |
AV junction rate= | 40-60 |
Ventricle rate= | <40 |
Absolute Refract: | P to mid T |
Relative refract: | Mid to end T |
Intropin 1-2 ug/kg/min: | promote renal, mesenteric blood flow? not |
Intropin 2-10 ug/kg/min: | inotropic effects |
Intropin >10 ug/kg/min: | vasopressor (constriction) |
Dig FX | +contractility, -dromotropic |
treat PACs: | verapamil, diltiazem |
treat Afib/flut: | Ca++/B/Dig,Procainamide |
treat SVT/PSVT: | adenosine, Ca/B/K block |
treat Vtach/fib: | Epi/vasopressin, lidocaine, amiodorone, MgSO4, procain |
I AA mechanism: | block influx of Na into both MC (phase 0) and PM cell (phase 4)... - conductivity and + refractory time; - automaticity (- HR) |
II AA mechanism: | Block the B1 receptors |
III AA mechanism: | slow efflux of K+ out MC, so repolarization +; +absolute refractory time; -conduction; -automaticity (- K out of cell, -phase 4 steepness |
IV mechanism: | -Ca influx (-HR), prevents SM contraction, vascular relaxation |
adenosine mechanism: | stimA1,-AV cond,-HR, +vasoD |
MgSO4 mechanism: | return ion balence esp. during CPR |
treat acute HT | Nipride |
treat + precap arteriole R | Nipride, Adalat, Capoten, Vasotec |
treat + precap venule R | Morphine |
Persantine FX | (dypyrimidamole) inhibits platelet aggregation |
Cardiazem FX | (diltiazem) -Mi02, -HR, vasoD |