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Immuno Jamie
Ch 2
Question | Answer |
---|---|
A synonym for an antigenic determinant is: | Epitope |
Genetically different individuals of the same species are referred to as : | Allogenic |
Antigenic substances can be composed of: | Lg polysaccharides, proteins and glycoproteins |
The most important characteristics of an antigen is: | Foreignness, degradability, molec. Weight |
An antibody is composed of : | Proteins |
19S | IgM |
What is the highest antibody in the serum or plasma of health person | IgG |
what antibody can exist as a dimer | IgA |
What antibody has the shortest life span | IgE |
Which antibody has no known sub classes | IgD |
Which antibody increases in infectious diseases, collagen and hematologic disorders? | IgG |
Which antibody is produced early in an immune response? | IgM |
Which antibody is the predominant immunoglobulin in secretions? | IgA |
What is the primary cell membrane immunoglobulin? | IgD |
Which antibody mediates some types of hypersensitivity reactions? | IgE |
Dominate type found on all animals in a species | Isotype |
Found on the immunoglobins of some but not all of a species | allotype |
individual determinants characteristic of each antibody | idotype |
what is the sequence of events for a typical immune response | Lag phase, log phase, plateau, decline |
Which of the following is false in an anamnestic response vs a primary response | IgM is predominate |
Which type is capable of placental transfer? | IgG |
ability of an antibody to combine with one antigen vs another | specificity |
Strength of a bond between a single antigenic determinant and an individual combining site | Affinity |
Strength with which a multivalent antibody binds to a multivalent antigen | avidity |
non-covalent combination of an antigen with its respective specific antibody | Immune complex |
What are the types of bonds involved in antigen-antibody reactions | Hydrophobic, hydrogen, VanDerWaals |
Monocovalent antibodies have also been referred to as what? | incomplete antibodies |
Antibody engineered to bind to a single epitope, purified from a single cell, are used to classify and identify specific cellular membrane characteristics | Monoclonal antibody |
Antigens are characterized by : | usually Lg organic molecules, glycolipids or glycoproteins, also called immunogens |
Antibodies are also referred to as- | Immunoglobulins |
Accounts for 10% of the Ig pool, largely confined to the intravascular system | IgM |
Diffuses more readily into extra vascular spaces, neutralizes toxins, and binds to microorganisms | IgG |
Found in tears, saliva, colostrum, milk, and intestinal secretions | IgA |
Mediates some types of hypersensitivity | IgE |
Makes up less that 1% of the total immunoglobulins | IgD |
What is the short chain of an Ig Called? | Fab Section |
What is the long or heavy chain of an Ig Called? | Fc Section |
In the Immune "bell curve" what are the 4 areas called, how are they different between 1st exposure and the 2nd exposure? | "A Lag phase B Log Phase C Plateau D Decline Phase |
What are the characteristics of secondary response | IgG is predominant, It has a shorter Lag phase, more gradual decline |
Bonding of antigen to antibody happens exclusively in | Noncovalent bonding |
The strongest bonds result from what? | Goodness of fit |
Monoclonal have what characteristics | cloned from single cell, purified antibody, engineered to bind to a single antigen |
T or F, IgM is predominate in a secondary response | False |