click below
click below
Normal Size Small Size show me how
Adrenal Gland
Clin Chem Exam 2
Question | Answer |
---|---|
What are the 3 layers of the adrenal cortex? | zona glomerulosa, zona fasciculata, zona reticularis |
Zona glomerulosa is related to what hormone? | Mineralocorticoids (aldosterone) |
Zona fasciculata is related to what hormone? | Cortisol (glucocorticoid) |
Zone reticularis is related to what hormone? | Androgens |
Where are the aromatic amines located? | adrenal medulla |
Cortisol is highest at what time of day? | 8-10am |
Synthesis and release of corticosteroids is stimulated by ________ | ACTH |
_______ plasma cortisol is bound to CBG | 90% |
Adrenal tumor lab values | decreased ACTH, decreased CRF, increased cortisol |
Adrenal nodular hyperplasia lab values | Massive amounts of cortisol produced |
Pituitary Cushings syndrome | increased ACTH, increased cortisol, decreased CRF |
Aldosterone is synthesized in the ________________ | zone glomerulosa |
Aldosterone is controlled by the __________ system | renin-angiotensin system |
Primary Conn's disease (hyperaldosteronism) is due to what? | overproduction of adrenal cortex (inc aldosterone, inc Na retention, inc hypertension) |
Secondary Conn's disease is caused by | CHF, nephrotic syndrome, increased renin production, cirrhosis |
In the zone reticularis, hormone synthesis is under the control of ____________ | ACTH |
common defect in the zona reticularis is __________________ | androgenital syndrome (21-hydroxylase deficiency) |
Congenital adrenal hyperplasia is due to __________ | an inherited defect in the genes of 1 or several steroids. |
What is the most common deficiency in congenital adrenal hyperplasia? | 21-hydroxylase followed by 11B-hydroxylase |
Lab results for congenital adrenal hyperplasia? | Decreased cortisol and aldosterone, increased ACTH and androgens |
Diagnosis for congenital adrenal hyperplasia? | Increased plasma 17-hydroxyprogesterone |
Testosterone is metabolized into what? (2) | Dihydrotestosterone and androtenedione |
What are the 17-ketosteroids? | metabolites of androgens secreted by both the testes and the adrenal gland |
What method is best to measure 17-KS? | Zimmerman reaction at 520nm-------purple compound |
The adrenal medulla contains ________________ | catecholamines |
2 major catecholemines are : | epinephrine and norepinephrine which are synthesized from phenylalanine |
Catecholamines are ____________ biologically active | 100%------------half life of 1min |
Catecholamines are rapidly metabolized by ____________ | catechol-O methyltransferase and monoamine oxidase |
What is the primary metabolite of epinephrine and norepinephrine? | VMA |
Catecholamines are metabolized to ___________ and ____________ | metanephrine and VMA |
What is pheochromacytoma? | Tumor of the chromatin cells of the adrenal medulla due to increased epinephrine and norepinephrine |
How to diagnose pheocytochroma? | Elevated plasma catecholamines and increased urinary VMA and metnaephrines |