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Ch End 3
Question | Answer |
---|---|
Self-renewal and pluripotential differentiation potential are characteristics of: | B. stem cells |
Precursor cells that are morphologically recognizable are found in the | C. maturing cell compartment |
The CFU-EMk gives rise to: | D. erythrocytes and megakaryocytes |
Hematopoietic cells derived from the CFU-GEMM | platelets, eosinophils, erythrocytes ... (NOT lymphocytes!) |
Cell is most sensitive to erythropoietin: | D. CFU-E |
Considered “early acting, multilineage” cytokines | GM-CSF, SCF, IL-3 |
a cytokine with multiple biologic activities | Pleiotrophy |
Cytokine regulation in which the cytokine is not secreted by the producing cell but remains membrane bound, necessitating direct cell-cell contact to achieve the desired effect is: | C. juxtacrine |
Thought to be negative regulators of hematopoiesis | TGF beta, TNF, MIP-1alpha |
The hematopoietic microenvironment is composed of: | C. marrow stromal cells and extracellular matrix |