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Pharm ch12

Pharmacology Chapter 12 Hematologic Drugs

Anticoagulants decrease the body’s ability to form thrombi (clots)
Abnormal thrombus formation can lead to floating clots called emboli
An embolus can become lodged in a stenosed (narrowing) artery + cause an infarct (obstruct)
Common infarcts include: 1. Myocardial infarction (MI). 2. Cerebral vascular accident (CVA).
A MI (myocardial infarction) is AKA a “heart attack” or “coronary.”
A CVAs (Cerebral vascular accident) is AKA a “stroke.”
The layperson calls anticoagulants “blood thinners.”
Common anticoagulant medications include: 1. heparin (subQ injection). 2. warfarin AKA Coumadin. 3. Plavix. 4. ASA (aspirin). 5. dipyridamole AKA Persantine 6. Lovenox (subQ injection). 7. Pradaxa 8.Xarelto
Coumadin (warfarin) requires periodic coagulation monitoring.
Vitamin K rich foods to avoid when taking Coumadin (warfarin) include: kale, Brussels sprouts, broccoli, asparagus, and spinach.
Plavix is a common prophylaxis for MIs (myocardial infarction{s}) and CVAs (cerebral vascular accident{s}).
Plavix requires periodic coagulation monitoring
Plavix use has been linked to thrombotic thrombocytopenic purpura (TTP).
Thrombotic thrombocytopenic purpura (TTP) can cause bleeding tendencies, hypochromic anemia, and kidney failure.
Persantine (dipyridamole) requires periodic coagulation monitoring
Pradaxa, Lovenox and Xarelto do not require periodic coagulation monitoring
Bleeding problems can occur if ASA or Coumadin (warfarin) are combined with gingko biloba, garlic, ginger, and NSAIDs
Thrombolytic (tPA) medications are administered to break up thrombi already formed.
Common thrombolytic (tPA) medications include: 1. streptokinase AKA Streptase. 2. alteplase AKA Activase. 3. tenecteplase.
The layperson calls thrombolytics “clot busters.”
A drug administered as a heparin antagonist is called protamine sulfate.
A medication used as a coagulant is vitamin K AKA Mephyton.
Created by: Patti Belfi Reed Patti Belfi Reed