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Stack #116283
Antibiotic Characteristics
Antibiotic | Characteristics |
---|---|
Penicillins | *possess beta lactam ring essential to their function *selectively interfere with cell wall synthesis *ineffective orgs w/o peptidoglycan or cell wall *maximally effective on actively proliferating bacteria *most widely effective antibiotic |
Cephalosporins | **beta-lactam antibio related to penicillin **bactericidal **same M.O. as penicillin **resist beta-lacatamases that inactive penicillin |
Tetracyclines | ***target 30s subunit of bacterial ribosome ***block access amino acyl-tRNA to mRNA-ribsome complex ***inhibit bacterial protein synthesis ***bacteriostatic |
Aminoglycosides | ****inhibit bacterial protein synth ****only effective against aerobes ****O2 dependent syst moves antibio across cell membrane ****bactericidal |
Macrolides | o*macrocylic lactone structure o*Erythromycin, clarithromycin, azithromycin o*irreversibly bind to 50s subunit, block prot synth o*bacteriostatic, bactericidal at higher concentrations |
Fluoroquinolones | o**inhibit bacterial DNA replication by interfere with DNA gyrase o**binds enzyme and DNA complex, leads to DNA clevage o**bactericidal |
Vancomycin | o***tricyclic glycopeptide o***inhibit synth of bact cell wall and peptidoglycan polymerization o***useful: people with beta-lactam allergy and gram (+) orgs |