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Lecture 7

Intestinal Protozoa - Amoeba

What is the definition of dysentery diarrhea with gross or occult blood in stool
What is considered persistent diarrhea? >= 14 days
what is the peak age of incidence in developing countries? 6-11 months of age
What is the definition of diarrhea? 3 or more liquid stools within 24 hour period (not including breast-feeding babies)
true/false: diarrheal and respiratory diseases are the leading causes of deaths in the developing world true: 3.2-3.5 million/year!
How often are the etiologic agents for diarrhea identified? <60% of the cases
What three known parasites cause diarrhea? Giardia lamblia, Cryptosporidium parvum, Entamoeba histolytica
Which parasite is a major cause of diarrhea in patients with AIDS? Cryptosporidium parvum
What three invasive diseases in addition to diarrhea does Entamoeba histolytica cause? dysentery, colitis, liver abscess
What are 5 risk factos for amebiasis? 1.hispanic/asian/pacific islander (50% of reported cases) 2. travelers 3. institutions for mentally retarded 4. Men who have sex with men 5. male (90% amebic liver abscesses are in men)
What are the symptoms of amebic colitis? 1. symptoms greater than 1 wk. 2. diarrhea 3. heme + stool 4. weight loss 5. fever >38 C
Why is diagnosis of Entamoeba histolytica difficult? Microscopy cannot distinguish betw. E. histolytica and E. dispar and E. moshkovskii which are nonpathogenic
Which is the most sensitive and specific way to diagnose amebic colitis? Stool antigen test
Who is more likely to get amebic liver abscess, males or females? Males:females 10:1
What are the symptoms and labs abnormalities in amebic liver abscess? symptoms greater than 4 wks, diarrhea, fever, right upper quadrant pain, leukocytosis, anemia abnormal liver enzymes, elevated bilirubin
What is the most sensitive method for detecting amebic liver abscess? Serum Antigen (unlike with colitis)
What is the tissue active agent for amebiasis? Metronidazole or tinidazole or ornidazole
What is the luminal agent for amebic colitis? paromomycin
Created by: UVAPATH4