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Hem2 Chp29
Practice for Hem2 Del-Tech Owens chapter 29
| Question | Answer |
|---|---|
| Most malignancies of the hematopoietic system are acquired __ __. | genetic diseases |
| Most leukocyte malignancies are not __. | localized |
| Most leukocyte malignancies are __ at the initiation of the malignant process. | systemic |
| For most leukocyte neoplasms, the direct cause of the malignancy is __. | unknown |
| Known causes of leukocyte neoplasms include: (4 answers) | environmental toxins, viruses, chemotherapy, familial predisposition |
| The FAB (French-American-British) classification system for leukocyte neoplasia is based primarily on __ and __ __. | morphology and cytochemical staining |
| The WHO (World Health Organization) classification system for leukocyte neoplasia is emphasizes __ and __ changes. | molecular and cytochemical changes |
| A single mutation can lead to a __ transformation of a cell. (Chromosomal transformation = mutation) | malignant |
| Chromosomal transformations in hematologic malignancies illustrate that a single mutation can least to a malignant transformation by disrupting the __ __ of the cell. | molecular machinery |
| Most chromosomal transformations (mutations) in leukemias involve __. | oncogenes |
| Tumor suppressor genes contribute to the process of malignancy only if both alleles have been __ or __. | lost or inactivated |
| The formation of oncogenes or the loss of tumor suppressor genes has molecular effects on the __ and __ of hematologic tissues. | proliferation and differentiation |
| The 5 categories of treatment for leukocyte neoplasms are: | chemo, radiation, supportive, targetd, stem cell transplantation |
| Which virus is known to cause lymphoid malignancies in humans? | Epstein-Barr (mono) |
| Tumor suppressor genes cause cancers (like leukemia) when mutations result in a failure to __ __ __. | prevent malignant processes |
| Oncogenes can be said to react in a dominant fashion because a mutation in a __ __ is enough for malignancy to develop. | single allele |
| True of false: Acceleration of DNA catabolism is one of the cellular abnormalities produced by oncogenes. | false |
| Three cell abnormalities caused by oncogenes are: | apoptotic failure, suppression of DNA transcription, disruption of cell cycle processes |
| What are the 2 major subgroups of chemotherapeutic agents? | phase specific and phase nonspecific |
| G-CSF is a supportive treatment for leukemia because it reduces the risk of __. | infection |
| Imatinib is a __ __ treatment for leukemia. | targeted therapy |
| Monoclonal antibodies can kill cancer cells by what 3 mechanisms? | 1) binding to the cancer cells and causing the immune system to destroy them 2) activating complement on the cell's surface 3) increasing the rate of apoptosis in the cancer cells |
| What 3 areas of the body are stem cells harvested from for transplantation? | 1) bone marrow 2) peripheral blood 3) umbilical cord blood |
| Allogeneic transplantation has a __ long-term success rate than autologuous bone marrow transplantation. | better |
Created by:
IsaacJ
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