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Path 22
Melanocytic Tumors
| Question | Answer |
|---|---|
| What is the origin of melanocytes | Melanocytes migrate from the neural crest and arrive in the epidermis in the 8 to 10 week fetus |
| Melanocytes are identified ultrastructurally by the distinctive appearance of their | melanosomes |
| What is the name for flat, brown to black pigmented spots that show increased numbers of melanocytes in the basal cell layer | Lentigo |
| What is the syndrome that typically has multiple lentigine in a perioral distribution on the hands and feet | Peutz-Jeghers Syndrome |
| Is it an increase in the number of melanocytes or increase in the amount of melanin that produces the ephelis, or freckle | increased amount of melanin |
| What is a lesion that looks like a freckle but is much larger | Cafe au Lait Macule |
| The presence of 6 or more Cafe au Lait Macules larger than 1.5 cm is highly suggestive of? | neurofibromatosis |
| What are the three classifications of nevi based on location | Junctional, Compound, and Intradermal |
| What is another name for Epithelioid Cell Nevus | Spitz's nevus |
| Where is a blue nevus most likely to be seen | on the buttock, dorsa of the hands and feet and face |
| T/F Congenital Nevi are common | False most nevi are not congenital |
| When is the median age for diagnosis with Malignant Melanoma | fifth decade |
| Where do most malignant melanomas occur in people with darker skin | palms, soles, under nails, and on mucus membranes |
| Would there likely be more malignant melanoma in Northern or Southern Norway | Northern (incidence increases with latitude) |
| What are the three major growth phases of malignant melanoma | Radial and Vertical |
| This type of Melanoma comprises approximately 70% of all malignant melanomas it has a long radial growth period before entering vertical growth | Superficial spreading malignant melanoma |
| This Melanoma has almost no radial growth phase | Nodular malignant melanoma |
| What is the most common melanoma occuring in Blacks, Hispanics, Asians, and American Indians | Acral Lentiginous Melanoma |
| What does Level 1 indicate | Intraepidermal or in situ |
| What does Level 2 indicate | Invades papillary dermis |
| What does Level III indicate | fills adn expands the papillary dermis |
| What does Level IV indicate | invades the reticular dermis |
| What does Level V indicate | invades subcutaneous fat |
| What is now regarded as the single most useful histopathologic indicator of prognosis in melanoma | The thickness measurement |
| What are some additional microscopic parameters that have soe predictive value | ulceration, regression, mitotic rate, degree of lymphoid infiltration of tumor and presence of micrometastases within the lesion |
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UVAPATH1
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