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Step 1 12.22.12 (2)
Endocrine I
Question | Answer |
---|---|
What are the embrologic origins of the adrenal cortex and mudulla? | cortex= mesoderm, medulla= neural crest cells |
What are the 6 histological layers of the adrenal gland? | 1. capsule 2. zona glomerulosa 3. zona fasiculata 4. zona reticularis 5. medulla 6. chromaffin cells |
What is the primary regulatory control on the zona glomerulosa? | renin-angiotensin |
What is the secretory products of the zona glomerulosa? | aldosterone |
What is the primary regulatory control on the zona fasciculata? | ACTH, hypothalamic CRH |
What are the major secretory products of the zona fasciculata? | cortisol, sex hormones |
What is the primary regulatory control on the zona reticularis? | ACTH, hypothalamic CRH |
What are the major secretory products of the zona reticularis? | sex hormones ( androgens) |
What is the primary regulatory control on the medulla? | preganglionic sympathetic fibers |
What is the major secretory products of the adrenal medulla? | catechomaines ( NE, Epi) |
What is mnemonic for the products of the different parts of the adrenal gland? | GFR(glomerulosa, fasciculata, reticularis)= salt (Na+ aldosterone), sugar ( glucocorticoids), Sex (androgens). farther down = sweeter |
Where is a pheochromocytoma located? | adrenal medulla |
Who gets neuroblastoma? | children |
What is a major difference between pheochromocytoma and neuroblastoma? | pheochromocytoma causes spisodic HTN, neuroblastoma doesnt |
What is the morphology of the fetal adrenal gland? | outer adult zone and inner active fetal zone. adult zone is dormant during early fetal life but secretes cortisol late in gestation |
What controls cortisol secretion in the fetal adrenal? What does it do? | acth and CRH from fetal pituitary and placenta. responsible for fetal lung maturation and surfactant production |
What is the drainage of the right adrenal gland? | Right adrenal--> right adrenal vein--> IVC |
What is the drainage of the left adrenal gland? | left adrenal-->left adrenal vein-->left renal vein-->IVC |
What is the posterior pituitary and what does it principally make? | neurohypophysis, derived from neuroectoderm. produces ADH (vasopressin) and oxytocin |
What is the function of neurophysins? | carry ADH and oxytocin from hypothalamus to posterior pituitary glands |
What is the embryological origin of the anterior pituitary gland? What hormones does it make? | from oral ectodemr (Rathke's pouch). makes FSH, LH, ACTH, TSH, prolactin, GH, melanotropin (MSH) |
What does the alpha subunit of the anterior pituitary gland make? | common subunit to TSH, LH, FSH, hCG |
What does the beta subunit of the anterior pituitary gland do? | determines hormone specificty |
What is a mnemonic for the basophilic pituitary hormones? | B-FLAT: basophilic- FSH, LH, ACTH, TSH |
What pituitary gland horomones are acidophils? | GH, prolactin |
What is a mneomic for the hormones made by the anterior pituitary gland? | FLAT PiG: FSH, LH, ACTH, TSH, Prolactin, GH |
What 3 types of cells are found in islets of Langerhans? What do they do? | islets arise from pancreatic buds and contain: 1. alpha: glucagon (peripheral) 2. Beta: insulin (central) 3. delta: somatostatin (interspersed) |
When is insulin made and by what cells? | made in beta cells of pancreas in response to ATP from glucose metabolism closing K+ channels and depolarizing cells |
Why do you need insulin? Does it cross the placenta? | required for adipose and SM uptake of glucose. it does not cross the placenta |
What are the inhibitory effects of insulin? | inhibits glucagon release by alpha cells |
What are some key regulatory forces on insulin? | hyperglycemia, GH, cortsiol= incr insulin. hypoglycemia, somatostatin= decr insulin Beta agonists= incr insulin release, alpha agonists= inhibit insulin release |
Is serum C peptide present with exogenous insulin intake? | no |
What is a mnemonic for cells which do not require insulin for glucose uptake? | BRICK L: Brain, RBCs, INtestine, Cornea, Kidney, Liver |
What do the brain and RBCs use for glucose uptake? | GLUT 1 |
What do the Beta islet cells, liver, kidney, and SI use for glucose uptake? | GLUT-2 |
What is GLUT 4? | used by adipose and SM for glucose uptake, responds to insulin |
What does the brain use nromally vs in starvation state for energy? | uses glucose normally but will use ketone bodies in starvation |
Can RBCs ever use anything but glucose? | no! no mitochondria |
What makes glucagon and when? | made by alpha cells of pancreas. secreted in response to hypoglycemia, inhibted by insulin, hyperglycemia, and somatostatin |
What are the 3 major effects of glucagon? | 1.glyconeogensis, gluconeogenesis 2. lipolyisis, ketone production 3. inhibiton of insulin and further glucagon release |
What is the effect of TRH for hormones? | TRH causes TSH and prolactin release |
What is the effect of dopamine for hormones? | inhibits prolactin |
What is the effect of CRH fro hormones? | incr ACTH |
What is the effect of GHRH on hormones? | incr GH |
What is the effect of somatostatin in hormones? | inhbiits GH, TSH |
What is the effect of GnRH in hormones? | incr FSH, LH |
What is the effect of prolactin ion hormones? | inhibits GNRH |