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Path 5

Neoplasia I

How is Neoplasm different from hyperplasia Neoplasm is abnormal growth of tissue Hyperplasia is an increase in teh number of cells within an organ or tissue
Does hyperplasia respont to normal regulatory growth control mechanisms yes
what is metaplasia a reversible change in which one mature cell type is replaced by another mature cell type
what is dysplasia potentially reversible change characterized by atypical cellular features and increased mitotis rate
what are the two main examples of names that end in -oma that are actually malignant Carcinoma and Sarcoma
What is the origin of carcinomas epithelial origin
what is the origin of sarcomas mesenchymal / connective tissue origin
Leiomyo- indicates? Smooth muscle
Lipo- indicates? adipose tissue
rhabdomyo- indicates? skeletal muscle
Scirrhous indicates? hard
Medullary indicates? soft resembling bone marrow
colloid indicates? gelatinous mucinous
what are two exceptions to the rule of -oma being benign unless called carcinoma or sarcoma melanoma and lymphoma
what is cellular differentiation extent to which neoplastic cells resemble normal cells
What type of differentiation is exhibited by Benign Neoplasms well-differentiated
what grows faster benign or malignant neoplasms malignant
how to benign vs. malignant tumors differ in respect to mode of growth benign grows by expansion and malignant grows by invasion
What is growth fraction? proportion of cells within a tumor population that are in the replicative pool?
why does doubling time increase as the tumor size increases tumor outgrows blood supply
what is the most common route of metastasis lymphatic spread
what is the characteristic route of spread of carcinomas Lymphatic spread
what is the characteristic spread of sarcomas Hematogenous spread
what are two common sites of hematogenous spread lung and liver
what does grade refer to? degree of differentiation
what is staging based on? TNM (Tumor, Nodes, Metastases)
Created by: UVAPATH1