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Lecture 6


Also known as Singer’s nodule. A benign non-inflammatory reactive change usually localized to true vocal cords. Laryngeal Nodule
Etiology of Juvenile Laryngeal Papillomatosis Human Papilloma Virus (HPV)
Gross and Microscopic features of Juvenile Laryngeal Papillomatosis Gross: Multiple papillary growths on vocal cords.
Prognosis of Juvenile Laryngeal Papillomatosis High recurrence rate. Usually benign. Very rare development of squamous cell carcinoma.
Most common malignant tumor of the larynx Squamous cell carcinomas. Usually seen in men over the age of 40 years.
Risk factors of laryngeal squamous cell carcinoma Cigarette smoking, heavy ethanol consumption
(T or F) Glottic squamous cell carcinomas tend to have a higher rate of lymph node metastasis than transglottic tumors. False
Inflammatory swelling of the nasal mucosa. Soft polypoid masses, typically bilateral. Symptoms may include nasal obstruction and rhinorrhea. Inflammatory (Allergic) Polyps
(T or F) Inflammatory (Allergic) Polyps is associated with cystic fibrosis True
Presents with nasal obstruction, nasal stuffiness, and epitaxis. Unilateral growth. M>F. Two morphologic subtypes: Fungiform and Inverted. Sinonasal papilloma
(T or F) Fungiform subtype of sinonasal papilloma are typically benign. True
(T or F) Inverted subtype of sinonasal papilloma can progress to squamous cell carcinoma. True
Testosterone-dependent tumor that arises from the fibrovascular nidus in the posterolateral nasal cavity. Typically found in adolescent males. Angiofibroma
Risk factors of Squamous Cell Carcinoma Cigarette smoking and nickel ore exposure
Etiology of lymphoepithelium Strong association with EBV and Asian ancestry
Microscopic feature of Lymphoepithelium (1) Syncytial growth of polygonal epithelial cells with oval vesicular nuclei and prominent nucleoli. (2) Non-neoplastic inflammatory infiltrate (esp. lymphocytes).
Microscopic feature of estheioneuroblastoma (1) nests or sheets of uniform small cells with scant cytoplasm (2) neurofibrillary stroma (3) Homer Wright rosettes
Most common neoplasm of salivary glands. High incidence in females than males. Pleomorphic Adenoma (benign mixed tumor)
Most common location of pleomorphic adenoma and Warthin’s tumor Parotid gland
Microscopic feature of pleomorphic adenoma Admixture of epithelial (glands or cords of small cuboidal cells) and stroma (fibromyxoid +/- cartilaginous differentiation) components
(T or F) Malignant transformation of pleomorphic adenoma can either involve the epithelial and stroma components. False
Microscopic features of Warthin’s tumor Oncocytic epithelium overlying lymphoid stroma with follicles
Most common malignant salivary gland tumor in children Mucoepidermoid carcinoma
Most common tumor of minor salivary glands. Highly malignant tumor that has a high propensity for perineural invasion, greatly limiting the chances for complete surgical excision. Adenoid Cystic Carcinoma
(T or F) Intraparotid lymph nodes only receive metastases from regional primary tumors False
Created by: UVAPATH2