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CYP families
PK
Question | Answer |
---|---|
CYP1 | activation of procarcinogenic compounds substrates: caffeine, phenacetin inhibitor: furafylline |
CYP2 | important for drug metabolism |
CYP2A6 | metabolism of coumarin and nicotine (metabolite cotinine) effect on smoking behavior |
CYP2B6 | metabolism of anticancer drugs cyclophosphamide and ifosfamide |
CYP2C9 | principal CYP2C in liver substrates are weakly acidic (ex: NSAIDS, warfarin, tolbutamide, phenytoin) *2 and *3 have reduced catalytic activity |
CYP2C19 | 91% identity with CYP2C9 substrates: anticonvulsant mephenytoin, omeprazole, andtiplatlet drug clopodogrel (plavix) |
CYP2D6 | mainly present in the liver metabolis of somme drugs requireing biometabolism, substrates: mostly basic, any CNS drugs (codiene, amitriptyline and haloperidol), debrisoquine (antihypertensive) |
CYP2E1 | ethanol is both an inducer and substrate industrial chemicals are substrates, many be activated to carcinogins |
CYP3A4 | major cyp in human liver responsiblile for metabolism of 50% of drugs major p450 in epithelial barrier of the small intestine |