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diabetes dosage

Pharmacotherapeutics

QuestionAnswer
glyburide sulfonylurea 1.25-20mg po Qd MDD = 20 mg CI when CrCl<50
glipizide sulfonylurea 2.5-20mg po qd-bid; MDD = 8 mg/d
glimepiride sulfonylurea 1-4 mg po QD, MDD=20 mg qd
Nateglinide(starlix) Meglitinides (short acting sulfonylurea)60-120mg po TID ac
repaglinide (prandin) Meglitinides (short acting sulfonylurea)0.5-16mg po ac; MDD: 16mg/d
metformin (glucophage) biguanides minimum effective dose 500mg po BID; MDD: 2550 mg/d CI when CrCl<60
Pioglitazone (Actos) Thiazolidinediones 15-30mg po qd; MDD: 45 mg
Rosiglitazone (Avandia) Thiazolidinediones 4-8mg po qd; MDD: 8mg po qd
Acarbose (Precose) Alpha-glucosidase inhibitors 25mg po TID (titrate up) MDD: 50 mg TID
Miglitol (Glyset) Alpha-glucosidase inhibitors 25mg po TID (titrate up) MDD: 100 mg TID
Januvia (sitagliptin) Glipatins: Dipeptidyle Peptidase-4 Inhibitors (DPP-4)optimal dose 100mg qd – CrCL 30-49: 50mg – CrCl <30: 25mg
Tradjenta (linagliptin) Glipatins: Dipeptidyle Peptidase-4 Inhibitors (DPP-4) 5mg qd
Onglyza (saxagliptin) Glipatins: Dipeptidyle Peptidase-4 Inhibitors (DPP-4)2.5-5mg qd – CrCl <50: 2.5 mg
Byetta (exenatide) incretin hormones 5ug SC BID 60 min before meals, increase to 10 ug after 1 month if tolerable, MDD=20 ug/day CI when CrCl<30
Bydureon (Exenatide) incretin hormones 2 mg SC once weekly CI when CrCl<30
Victoza (liraglutide) incretin hormones start 0.6 g QD x 1 wk then 1.2 mg QD, MDD= 1.8 mg QD, given without regard to meals,
Symlin (pramlintide) Amylinomimetics start 15 ug, target 60 ug SC immediately prior to each meal (T1)or 60 ug, target 120 ug SC QAC
Created by: Kachmiel
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