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intracellular juncit
thatcher self study
| Question | Answer |
|---|---|
| these are tight junctions. they consist of numerous linking proteins that tie the membranes of adjacent epithelial cells closely together around their apical perimeters. their purpose is to seal epithelial layers | zona occludens |
| transmembrane complexes that allow diffusion of small molecules between cells. each complex is hexagonal, with six polypeptides. there are twelve polypeptides per junction. | gap junctions |
| these link microfilament of cytoskeleton one cell with that of another cell. they are more like focal adhesions than spot desmosomes or hemidesmosomes. they anchor microfilaments to the membrane. | zona adherens (belt desmosomes) |
| microfilament bundles attached to zonula adherens, which encircle the apical perimeter of epithelial cells just below zonula occludens. | circumferential belt. constriction of these microfilaments around the "necks" of the cells pull them into bottle shaped conformations. this distortion of multiple cells in an epithelial sheet causes it to fold. |
| these are scattered spot welds joining two cells along their lateral surfaces. they serve to tie together the cytoskeletons of multiple cells across a tissue | spot desmosomes (macula adherens) |
| an autoimmune disorder that attacks one of the transmembrane linker proteins | pemphigus vulgaris |
| complexes that anchor epithelial cells to the extracellular matrix of the basal lamina | hemidesmosomes |
| a heterodimeric transmembrane protein that binds a number of factors on both sides of the membrane. besides hemidesmosomes, it is also use dby focal adhesions, where it links microfilaments to fibronectin. | integrin |
| anchor migratory cells such as fibroblasts and metastatic cancer cells to a substratum. | focal adhesions |
| transmembrane proteins of RBCs. their primary funciton is to serve as transport proteins. however, they ar ealso use das junctions, anchoring the filament cytoskeleton to the plasma membrane, thereby maintaining the characteristic RBC shape. | band 3 anion transporter. |
| ties sarcomeres of muscle cells to their plasma membrane and their extracellular matrix. it is bound to actin and to a glycoprotein complex in the plasma membrane, which in turn interacts with components of the extracellular matrix. | dystrophin |
Created by:
aferdo01
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