M2 Pharm Cards Word Scramble
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| Drug Name | Uses | MOA/Pharm | Misc/Side Effects |
| Mechlorethamine (N-mustard) | Hodgkins & NHL | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Vesiant activity = skin blistering |
| Melphalan (N-mustard) | Breast & Ovarian cancer | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Vesicant |
| Chlorambucil (N-mustard) | CLL (po) | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Vesicant |
| Cyclophosphamide (N-mustard) | NHL, ALL, CLL, AML, CML | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Acrolein = Toxic metabolite --> hemorrhagic cystitis ( |
| Ifosfamide (N-mustard) | same as Cyclophosphamide, but for pts w/ liver disfunction. Increased half-life = 7 hrs | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Acrolein = Toxic metabolite --> hemorrhagic cystitis ( |
| Busulfan | CML | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | SE: Pulmonary fibrosis, hyperpimentation |
| Carmustine (Nitrosureas - IV) | Brain Tumors (very lipophilic), Multiple Myloma | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | CNS toxicity, Lymphocytopenia, Thrombocytopenia |
| Lomustine (Nitrosureas - PO) | Brain Tumors, Multiple Myloma | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | see carmustine |
| Streptozocin | Pancreatic Islet Tumors | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Less BM toxicity, Renal & Hepato toxicity. |
| Dacarbazine | Hodgkins, SLL, Melanoma, Glioblastoma | MAO-I, also CYP activity | HTN rxns --> avoid tyramines & sympathomimetics |
| Procarbazine | Hodgkins, SLL, Melanoma, Glioblastoma | see dacarbazine | see dacarbazine |
| Cisplatin | Bladder, Testicular, Ovarian & Small Cell Lung Cancer | Platinum complex causes DNA cross-linking --> inhibit RNA & DNA Pol. | Ototo & Renal toxicity, neuropathy, BM suppression |
| Oxaliplatin | Bladder, Testicular, Ovarian & Small Cell Lung Cancer | Platinum complex causes DNA cross-linking --> inhibit RNA & DNA Pol. | Ototo & Renal Toxicity, neuropathy, BM suppression |
| Carboplatin | Colorectal Cancer | Platinum complex causes DNA cross-linking --> inhibit RNA & DNA Pol. | BM suppression. Minor: ototo & renal toxicity and neuropathy |
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