Pharm2 Lect 4 Word Scramble
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Pharm2 Lect 4
Pharm2 Cholinomimetics
| Question | Answer |
|---|---|
| Direct Muscarinic Agonists | 1.Acytelcholine. 2.Methacholine. 3.Bethanechol. 4.Pilocarpine. 5.Carbachol. 6.Cevimeline. 7.Muscarine. |
| Adverse effects of direct Muscarinic Agonists | 1.Inc Salivation. 2.Inc Sweating. 3.Intestinal cramps. 4.Aggravate Ulcer. 5.VD/Hypotension (Endothelial NO). 6.Bradycardia or reflex tachycardia (M2). 7.Asthma. 8.Near vision (lense rounding). 9.Miosis. |
| Direct Muscarinic Agonists: Acetylcholine & Methacoline | Mech of action: Directly binds to M receptors. |
| Direct Muscarinic Agonists: Pilocarpine | 1.Mech of action: Direct M agonist causing salivation, Inc aq humour outflow/drainage for Open & narrow angle glaucoma. 2.Oral, Topical-EYE. 3.Used to treat Open & Narrow Angle glaucoma, Sjogren's syndrome, radiation induced dry mouth. |
| What is the only drug used to treat NARROW angle Glaucoma (all others are for open angle)? | Pilocarpine |
| How does Pilocarpine affect Open angle glaucoma differently from Narrow angle glaucoma | OAG-Contracts ciliary m.: pulls on trabecular meshwork: open holes: Inc outflow of aq humor NAG-contract the iris sphincter smooth m.: induce miosis: pulls the iris away from the trabecular meshwork: Inc outflow of aq humor: dec IOP |
| Direct Muscarinic Agonists: Bethanechol | 1.Mech of action: directly activates M receptors. 2.Used to treat Post-op abdominal distention & urinary retention, Neurogenic atony of the bladder w/o retention. **used to treat NONOBSTRUCTIVE symptoms. |
| Direct Muscarinic Agonists: Carbachol | 1.Mech of action: Directly M agonist that contracts ciliary muscles Inc outflow/drainage of aq humour. 2.used as a 2nd line of defense after Pilocarpine for OAG. |
| Direct Muscarinic Agonists: Cevimeline | 1.Mech of action: Direct M agonist selective on salivary glands. 2.Bioav: longer lasting salivation effect (4-6hrs). 3.Used to treat Sjogren's syndrome (newer than Pilocarpine) |
| Direct Muscarinic Agonists: Muscarine | 1.Mech of action: direct M agonist. 2.From: Mushrooms. |
| Problems with ACh as a drug? | 1.Very short half life. 2.Activates N & M receptors. 3.TOO MANY SIDE EFFECTS. |
| What M agonist would be best to treat Urinary bladder and GI issues? | Bethanechol |
| Would Bethanechol be good to treat BPH? | NO!! it is and OBSTRUCTIVE urinary bladder w/ retention. **Bethanechol only affects NONOBSTRUCTIVE. |
| What is Sjogren's Syndrome? | Autoimmune disease attacking salivary and tear glands. **Treat with: 1.Pilocarpine, 2.Cevimeline (longer lasting and fewer side effects). |
Created by:
WeeG
on 2012-02-26