Mucosal Immunity Word Scramble
|
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Question | Answer |
intestinal cellular turnover | shed and turnover 2-5 days |
mucosal type I | single-layered epithelium |
mucosal type II | stratified epithelium |
organized lymphoid tissue | 1) tonsil 2) appendix 3) mesenteric lymph nodes 4) Peyer's patches 5) isolated lymphoid follicles 6) cryptopatches |
peyer's patches | most in small intestine and highest in terminal ileum 1:2 ratio of T-cells/B-cells pick up antigens thru M cells |
isolated lymphoid follicles | structurally similar to Peyer's patches-->characterized by single follicle |
cryptopatches | submucosal collections of lymphoid cells precursors to isolated lymphoid follicles |
tonsil | palatine and nasopharyngeal |
appendix | blind-ended tube connected to cecum |
mesenteric lymph nodes | lie in between layers of mesentery (double layer of peritoneum that suspends jejunum and ileum from posterior wall of abdomen) |
TLR expression and ligands | expressed by bone marrow-derived cells and tissue stroma ex) epithelium, fibroblasts ligands: 1) PAMPs 2) peptidoglycans 3) LPS 4) dsRNA 5) flagellin 6) CpG |
TLR2 ligand | binds gram (+) bacteria |
TLR4 ligand | binds LPS |
TLR5 ligand | binds bacterial flagellin |
TLR9 ligand | binds CpG |
innate immunity | early capability to recognize and degrade pathogens general response to PAMPs mediated by epithelial cells, TLRs, macrophages, mast cells, eosinophils, NK cells |
adaptive immunity | memory responses to previous exposure to pathogen very specific but delayed responses mediated by T and B lymphocytes |
hygiene theory | early and frequent exposure to infectious organisms boosts the immune system probiotic bacteria alter intestinal flora and immunity (and do not colonize) |
adaptive immune mechanisms | 1) FAE-->exploited by pathogens bc of its uptake 2) oral tolerance-->lack of immune response to food 3) commensal bacteria 4) IgA |
Ulcerative Colitis | IBD that usually presents with bloody diarrhea continuous distribution restricted to superficial epithelium of colon genetic association with HLA*DR2/DR3*QD2 |
Crohn's disease | IBD-usually presents with abdominal pain, intestinal obstruction, perforation chronic intermittent, transmural, segmental inflamm. c'some 16 (NOD2 gene)-->20x more susceptible-->reduced NF-kB activation ATG16L1 (autophagy) variants increases risk |
Created by:
kphom001
Popular Medical sets