2VCOMPharmacology 1 Word Scramble
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Question | Answer |
o Examples of antimicrobials | Natural: Penicillin, cephalosporin C Synthetic: Sulfamethoazole, Trimethoprim, Quinolones (ciprofloxacin, levofloxacin |
• Antimicrobial spectrum fall into what categories | Narrow, extended, broad |
• MIC stands for what? | Minimal inhibitory concentration |
• Tests for MIC are what two? | Etest and Disk diffusion |
• What are the types of microbial resistance? | o Innate resistance: Microbe lacks drug target of the chemotherapeutic agent. o Acquired resistance: Microbe that has undergone a change. Change compensates for the presence of the drug. |
•How do bacteria acquire resistance? | o Mutation o Transfer |
• Why does drug fail to reach its target? | o Can’t penetrate cell wall/membrane due to change in structure or because of drug efflux pumps o Metabolic rxns inactivate drug o Mutations in target preclude binding of drug to target |
• Explain the reasons for antibiotic resistance in patients | Prescribing an insufficient duration, an insufficient dose, an antibiotic that is only o Prescribing when not needed. o Stopping antibiotic use as soon as symptoms disappear, Taking antibiotics without physicians supervision. |
• What are the targets of antibacterial drugs? | o Replication, metabolism, protein production, & certain structures i.e cell wall |
• Name some cell wall inhibitors | The following antibiotics o b-lactam Penicillins (and their derivatives). Cephalosporins (four generations). Monobactams. Carbapenem. (b-lactamase inhibitors). o Others Bacitracin. Fosfomycin. Vancomycin |
• Name the Narrow spectrum penicillins | Penicillin G Penicillin V |
o Name the Penicillinase resistant penicillins | Nafcillin |
o Name the Extended spectrum penicillins: | |
o Name the b-lactamase inhibitors: | Competitive inhibition of b-lactamase: Aren’t antibiotics Clavulanate Sulbactam |
Created by:
VCOM2013
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