Vagina, Vulva, Cervi Word Scramble
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Question | Answer |
Clear cell carcinoma (vaginal) | unlike ovarian this arises in young women whose mothers used DES (glands of clear cells that HOBNOB (nucleus protrudes out)) |
Embryonal Rhabdomyosarcoma | sarcoma of primitive skeletal muscle cells in children |
Rhabdomyosarcoma botryoid | tends to occur in vagina and bladder (grape like) protrudes from the vagina with cambian growth patter (treelike) 50% 5year |
Endocervical Polyp | BENIGN cervical lesion from the os can cause post coital bleeding (endothelium over thich walled blood vessel |
Adenocarcinoma in situ | Premalignant cervical lesion- in transformation zone associated with HPV, nuclear enlargement with loss of cytoplasm |
what is the main difference between low and high risk HPV | high risk inserts itself into the genome |
high risk HPV? low | high 16,18, 31,33 Low 8 and 11 |
What CIN gradings are high grade | CIN 2 and CIN 3 |
what percent of untreated high grade dysplasias progress to SCC | 70% |
two mechanisms of high risk HPV cancer causing | insert and inactivate p53 or activate retinoblastoma (uncontrolled DNA proliferation) |
what is the histiological apperance of chlamydia | follicular cervicitis |
what are two complications of chlamydia | endometritis (40%) and salpingitis (11%) |
Post chlamydia sequelae | PID, Tubal infertility, neonate pneumonia |
HSV2 | a virus that causes non-painful vesicles and shallow excruciatign ulcerations |
what are the three Ms seen in late Herpes Infections | Multinucleation, Margination(clear around nucleus) and Molding (push against each other) |
what happens if herpes is passes onto the child during birth | encephalitis, neurological damage, mental retardation |
Non-infectious cervicitis can be caused by? | chemical, mechanical damage but is often asymptomatic with infiltrate and squamous metaplasia |
Vulvular cysts Bartholin's Gland | hard to palpitation hiding behind the labia minora may mimick malignancy |
Lichensclerosis et Atrophicus | common cause of white changes in the vulva most often in post menopausal women may be painful Parchment paper like lesions |
what is the NON HPV squamous cell carcinoma | Lichen sclerosis et atrophicus |
Padget's disease | red eczematous with irregular borders in older women this is an intraepithelial proliferation of Malignant gland like cells that rarely invade below stroma thought to be sebaceous gland |
prognosis of padget's disease | slow progression with surgical removal being challenging due to irregular borders 15% of other women have malignancy elsewhere |
Melanoma | padgetoid spread of nest cells (10% of vulvar malignancies) |
survival of melanoma patients is based on | degree of invasion less than 1.5 mm great prognosis, more = 5% 5yr |
what is micro invasive scqamous cell carcinoma | SCC of less than 3 mm this is important because there is a decreased risk of spread and excellent prognosis |
Created by:
jmuame03
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