Derm Systemic 1 Word Scramble
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Question | Answer |
Autoimmune disorders with cutaneous signs | SLE, dermatomyositis, scleroderma, vasculitides |
endocrine disorders with cutaneous signs | diabetes |
immune disorders with cutaneous signs | dermatitis herpetiformis, urticaria/angioedema, sarcoidosis |
metabolic disorders with cutaneous signs | xanthelasma |
>__% of patients with SLE have skin findings | 85 |
subset of patients with __ have cutaneous, but not systemic disease | lupus erythematosus |
3 categories of skin manifestations of SLE | acute cutaneous, subacute cutaneous, chronic cutaneous (discoid lupus) |
aka discoid lupus | chronic cutaneous lupus |
other dermatologic manifestations of SLE | alopecia and oral ulcers |
__ is very common in those with lupus, sun exposure may trigger acute lesions | photosensitivity |
localized or generalized face, scalp, upper extremities (malar or butterfly rash), papules, papular urticaria, scaly plaques, discoid lesions, bullae, palmar erythema | acute cutaneous LE (ACLE) |
scaly plaques are more commonly associated with __LE | subacute cutaneous LE |
discoid lesions are more commonly associated with __ LE | chronic cutaneous LE |
__% of patients with SCLE have SLE | 50 |
typically start as small erythematous papules with scale, associated with anti-Ro and anti-La antibodies, | annular or papular (psoriaform) lesions associated with SCLE |
__% of SLE patients have discoid lesions | 25 |
non-specific lesions/rashes associated with SLE | lupus profundus (lupus panniculitis), vasculitic lesions (purpura), livedo reticularis, urticaria |
one of the idiopathic inflammatory myopathies; heliotrope is classic cutaneous lesion | Dermatomyosistis |
considered pathognomonic of dermatomyositis | Gottron's papules |
slightly raised pink, dusky red or violaceous papules over the dorsal sides of the MCP/PIP and or DIP joints, can occur over wrists elbows or knees (pathognomonic for dermatomyositis) | Gottron's papules |
macular rash over posterior shoulders/neck. seen in dermatomyositis | shawl sign |
macular photosensitivity rash over anterior neck, can aslo occur on face or scalp. associated with dermatomyositis | V sign |
nail findings of dermatomyositis | periungual erythema, telangiectasias, cuticle overgrowth |
systemic sclerosis | scleroderma |
localized scleroderma | morphea, linear scleroderma |
localized plaques or linear, band-like distribution, most common in women, peak age of onset 20-50, rarely progresses to systemic disease | localized scleroderma |
sclerodactyly, Raynaud's phenom, sclerosis of face, scalp, trunk, periungual and mat-like telangiectasia, pigmentation abnormalities, calcinosis cutis | systemic scleroderma |
erythematous or violaceous macular rash of eyelides, peri-orbital area, often accompanied by edema; DM | Heliotrope |
scleroderma epidemiology | F>M; 20-50 yrs |
systemic,immunologic,genetic disease manifesting in skin and/or joints | psoriasis |
psoriasis lesions: | Red scaling papules coalesce to round-oval plaques |
psoriasis epidemiology | 2.1% of US adults (4.5M); 1M psoriatic arthritis; 200K new cases/yr |
Psoriasis most common sites | scalp, elbows, legs, knees |
Psoriasis common findings | Chronic plaque; Erythroderma; Pustular; Guttate; Intertriginous |
Most common type of psoriasis | plaque psoriasis: erythematous oval plaques, distinct borders, w/silver-white scale |
Drugs that exacerbate psoriasis | Lithium; Beta-blockers; Antimalarials; Systemic steroids |
Factors that flare psoriasis: | Strep infxn; Injury or trauma; Drugs; Low humidity; Emotional stress; Overtreatment |
Guttate psoriasis | Small papules of short duration (weeks to months); Usually children and young adults; often after strep |
Most common type of psoriatic arthritis | asymmetrical arthritis |
Psoriasis etiology | T-cell-mediated hyperproliferation of epidermis -> inflammation of epidermis / dermis -> keratinocyte hyperproliferation |
Psoriasis: associated conditions | CVD, depression, lymphoma |
Silvery scaling plaques on extensor sensors. Ausptiz sign, Koebner phenomena; sausage fingers | Psoriasis |
Rat bite erosions on X-ray | Psoriatic arthritis |
Psoriasis: 5 variants = | plaque, pustular, guttate, inverse, erythrodermoid |
psoriasis tx | topical steroids & vit D; coal tar / ASA preps; topical retinoid prn; for severe: cyclosporine, MTX, PUVA |
von Zombusch syndrome | pustular psoriasis: emergency; diffuse pustules coalesce => lakes of pus; fever, malaise, high WBC |
erythrodermoid psoriasis = | generalized, over most of skin; hypermetabolic state requiring hospitalization |
psoriasis mgmt | Acitretin (0.5mg/kg; teratogen) vs MTX / Csteroid vs retinoids. |
psoriasis tx categories | Topical (tar & CS, vit D & A/retinoid); phototherapy (UVB); MTX; cyclosporin A; Biologics (alefacept / efalizumab) |
pemphigus vulgaris etiology | bullous autoimmune dz; IgG Ab => acantholysis => loss of cell-cell adhesion |
pemphigus vulgaris S/S | oral mucosa lesions precede skin by 6-12 mos; pain (no itch); Nikolsky sx |
pemphigus vulgaris tx | systemic tx: prednisone + immunosuppressives, azathioprine +/- MTX |
Pemphigus may be side effect of what med class? | ACEI |
Created by:
Abarnard
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