First Aid Neo Pharm Word Scramble
|
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
| Question | Answer |
| Folic acid analog that inhibits dihydrofolate reductase | Methotrexate |
| Pyrimidine analog that inhibits thymidylate synthase | 5-fluorouracil |
| Inhibitor of de novo purine synthesis | 6-mercaptopurine |
| Inhibits DNA polymerase | cytarabine |
| Alkylating agents used to treat Non-Hodgkin lymphoma, breast and ovarian carcinoma. Notable side effect of hemorrhagic cystitis | Cyclophosphamide, ifosfamide |
| Alkylating agent capable of crossing blood brain barrier | Nitrosureas (carmustine, lomustine) |
| Similar to alkylating agent, notable toxicities include nephrotoxicity and acoustic nerve damage | Cisplatin, carboplatin |
| Alkylating agent used to treat CML | Busulfan |
| Free radical generator and also intercalates DNA to from strand breaks ("A" in ABVD treatment for Hodgkins) | Doxorubicin (Adriamycin), daunorubicin |
| Used to treat childhood tumors (Wilm's tumor, rhabdomyosarcoma, and Ewing's sarcoma) | Dactinomycin (Actinomycin D; Children ACT out) |
| Free radical generator which can cause life threatening pulmonary fibrosis | Bleomycin |
| Topoisomerase II inhibitor | Etoposide |
| Steroid that triggers apoptosis | Prednisone |
| Estrogen receptor antagonist | Tamoxifen |
| Monoclonal antibody against HER-2 | Trastuzumab |
| Philadelphia chromosome bcr-abl tyrosine kinase inhibitor | Imatinib (Gleevec) |
| Binds tubulin blocking polymerization of microtubules and mitotic spindle formation | Vincristine, vinblastine |
| Binds tubulin hyperstabalizing microtubules and blocking mitotic spindle formation | Paclitaxel |
| Toxicity includes Cushing-like symptoms | Prednisone |
| Used for "metastatic" breast cancer | Trastuzumab |
| Increased risk of endometrial carcinoma | Tamoxifen |
| Do not use with allopurinol | 6-mercaptopurine (activated by xanthine oxidase; allopurinol is a xanthine oxidase inhibitor used to treat gout) |
| CNS toxicity | Nitrosureas (carmustine, lomustine |
| Reversible myelosuppression with leucovorin rescue | Methotrexate |
| Neurotoxic (areflexia, peripheral neuritis) paralytic ileus | Vincristine (Vinblastine is notable for bone marrow suppression) |
| Antineoplastic used for therapeutic abortion | Methotrexate |
| Androgen receptor antagonist | Flutamide |
| Recombinantly produced cytokine used to treat hairy cell leukemia | Interferon alpha |
| GnRH agonist used for the treatment of metastatic prostate carcinoma | Leuprolide, Goserelin, Nafarelin |
| Monoclonal antibody used for treatment of low grade non-Hodgkin lymphoma | Rituximab |
| Aromatase inhibitor used to treat breast cancer | Anastrozole |
Created by:
rahjohnson
Popular USMLE sets