HIV drugs Word Scramble
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Question | Answer |
CCR5 antagonist (MOA), | Maraviroc, CCR5 antagonist prevent the co-receptor to bind with HIV to help facilitate the fusion of HIV RNA. |
Maraviroc (Rights) ADR | CCR5 antagonist, Rash, SJS, GI, Hepatotoxicity, URTI, Drug interactions as CYP 3a4 inhibitor |
Fusion inhibitor (enfuvirtide) | SC BID (painful), |
enfuvirtide ADR | injection site painful rxn 98%, hypersensitivity rxn, increase in bacterial pneumoniae, nodule formation at the injection site |
NRTI meds (know class ADR: Lactic acidosis, hepatic steatosis & lipodystrophY) | ZELTA (Zidovudine, Tenofovir, Abacavir, Lamivudine, Emtricitabine) |
NRTI MOA | prevent conversion of RNA to DNA (reverse transcriptase) |
Abacavir ADR | NRTI: life threatening hypersensitivity (FARMS N/V) |
Tenofovir ADR | GI intolerance, renal impairment |
Zidovudine ADR | HA, bone marrow suppresion |
Lamivudine and Emtricitabine | minimal toxicity |
Integrase inhibitor (MOA) | it will prevent the integration of viral DNA into cellular DNA. raltegravir, elvitegravir, stribild |
Integrase inhibitor ADR of Raltegravir | CHIMP N/D (CPK elevation, Nausea, diarrhea, pyrexia, headache, myocardial infraction) |
Integrase inhibitor Stribild, Elvitegravir (cobicistat) | one tablet a day with food, don't use if CrCl < 70 or with other ART, Cobcistat is booster. |
Stribild | N/D, renal impairment, decrease bone mineral density |
Prevention: what can you do? Sexual | Practice CDC's ABC. Latex condom and water-based lubricant. Early ART, do TRUVADA for prophylaxis. Male circumcision Dental dams |
Prevention: what can you do? parenteral | testing/treatment for accidental needlestick. universal precautions. screening of donated blood/organs etc. clean needle programs. |
Perinatal: what can you do? perinatal | treat during pregnancy (don't use efavirenz). RNA count less than 1000. Elective C-section. avoid breastfeeding if safe alternative exists. |
Efavirenz Strength | NNRTI. well tolerated, low pill burden, PI option reserved for future use |
Efavirenz Weakness | CNS symptoms, possible teratogenicty,DI, rash, hepatotoxicity, resistance single mutation |
PCP prophylaxis Primary | Bactrim 1 ds, if sulfa allergy then dapsone. Start if CD4 < 200, stop if CD4 > 200 for > 3 months. |
PCP prophylaxis secondary | same as primary, only this time don't stop treatment if CD4 >200 |
Toxoplasma gondii | start bactrim ds qd if CD4 < 100 stop when CD4 > 200 for 3 months |
MAC (mycobaterium avium complex) | start azithromycin 1200 mg po qwk if CD4 < 50 Stop when CD4 > 100 for 3 months |
DI ART | CASHEW-G (contraceptive, antimicrobial (rifampin), antifungal, anticonvulsant, statins, herbals, ED, Gastric acid suppressant) |
Four vaccine u need to avoid | Varicella, Zostavax, MMR, live attenuated influenza vaccine |
Four vaccine u need to get | Pneumovax (at any CD4 above 200), inactive influenza (annually), Hep b (anti-HBc negative), Hep A (at risk plus negative anti-HAV) |
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Illusion
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